Early-Stage Biotech Value Creation: The Roles of Equity and Partnerships


WARNING TO THE READER: this piece is REALLY LONG.
Its genesis lay in my current efforts to develop a business/financing strategy for Decibel Therapeutics.  In that context, I have been giving thought to how others have been successful—and failed—in such endeavors. 
The piece starts with my thoughts. It is then followed by responses to these thoughts by three great thinkers (and friends) in the biotech industry: Mark Levin, John Maraganore, and Jeff Tong, who reviewed an earlier draft. My replies to their responses are also included. In fact, there are two rounds of responses and replies.
The publication of this piece on a blog, which has a “comment” functionality, is intended to enable additional colleagues in the industry (including you) to join the conversation if they/you so desire. Invariably I find that responses to my thoughts are much more insightful than anything I have to say.
In addition to being very long, the piece features extensive endnotes. I tried to move the bulk of my asides, philosophical musings, anecdotes from the history of biotechnology, etc. to endnotes to make the main text flow better. One can read the text without reading the endnotes. With respect to the historical anecdotes, at least one reviewer who is a biotech history buff loved them (albeit, flipping back and forth between the text and the footnotes is somewhat an act of masochism perhaps only appealing to fans of the writings of David Foster Wallace).  I make no claim to 100% historical accuracy or completeness. They are the best my failing memory has to offer and draw heavily on my first-hand personal experiences.
Thanks to Mark, John, and Jeff for consenting to the inclusion of their comments and for their encouragement to put this out there for consumption and participation by a broader audience.
==============================================
Prologue

Building a great, sustainable biopharmaceutical company requires so many things:

·        Great science
·        Great drug discovery and development
·        Great people
·        Great culture
·        Great vision and strategy
·        Great execution
·        Great investors

This piece addresses NONE of these.

Its sole focus is the STRATEGIC FINANCIAL aspect of building a great, sustainable biopharmaceutical company: how do you put the “gas in the engine” in the period before revenues and profits in a manner that enables financial investors (and your employees who hold stock/stock options) to enjoy a return on their investment (= increase in share price relative to their purchase price).

The appropriate financing strategy will be dictated by internal forces (the nature of your assets and vision) and externalities (the partnering and capital markets). There is no single strategy appropriate to every company in every environment. At the same time, the fact of the matter is that, in the period before you have product revenues, you have only two things to sell. The first is technology and information of current value to the customer (typically, a larger biopharmaceutical company). The second can be called “futures,” and those futures come in one of two flavors: equity (and instruments that look, smell, and taste like equity) and rights (marketing/profit participation rights) in/to the products (and the revenues they will produce) you are seeking to develop. As it were, you are selling participation in the future financial appreciation of the whole and/or of one or more of the parts. (Note: the sale of technology and information of current value to the customer can and most often involves a sale of rights.)

I make no claim of originality for the observations recorded here. In many, if not all, respects, they are obvious. If this rambling has any value, it will be found in having achieved the goal of philosophical inquiry described by Wittgenstein in Philosophical Investigations, Part I, Section 122: “A main source of our failure to understand is that we do not command a clear view…A perspicuous representation produces just that understanding which consists in ‘seeing connexions’.”
============================================

Chapter 1: The Basics

·        Value creation is not about the size of your market cap, or not directly about that. It’s all about share price appreciation.
o   Market cap is about the size of a CEO’s ego.
o   Share price is what pays for your (and your investors’) kids’ college educations.
·        You can create a large market cap without creating shareholder value by taking too much dilution early when your stock price is at its lowest. Therefore, be wary of early dilution.
·        Yet beware that corporate partnerships are not an end in and of themselves and are not a (purely) “non-dilutive” form of cash; they are an implement of strategic value creation.
o   Use them to contain early dilution but only if you can do so in a manner that does not give away the major sources of your future value creation.
·        Ours is a business in which you can spend yourself to death, but you can’t save your way to glory.
·        Therefore, under-spending/under-capitalizing and over-spending/over-capitalizing both represent sources of risk to exceptional value creation.
·        The art lies in balancing the two different sources of capital as they represent two different forms of dilution and in recognizing the relative risk of the two that applies to your specific situation.
·        Identify your specific situation at the given moment in your evolution and act accordingly.




Chapter 2: Product Companies

  • In general, if you are a “product-based, single or limited assets” company[1], your primary risks are either over-spending/over-capitalizing early (dilution) or partnering in a manner that sells off your long-term value-creation potential.
    • Your value is directly driven by the attainment of meaningful development milestones.
§  Drive your lead asset.
    • Do not partner away (the majority of) your rights early; use equity as funding, otherwise you will have given away the source of your longer-term value and be “back on the hamster wheel” trying to develop the next shot on goal.
    • Raise sufficient capital early; devote this early/expensive cash to driving to the value-inflection development milestones; but do not “over” capitalize too early.
      • Be sure to be realistic and not find yourself—when the inevitable hiccups occur—with the gas tank approaching “E”…venture capitalists in such situations often morph into vulture capitalists.
    • On the back of good data, raise more, large amounts of equity at higher prices: now is the time that the risk has shifted from over-capitalization to under-capitalization; keep doing so as you knock off the data-based milestones.
o   Achieve out-scale return via:
§  Get sold.
§  Get to market with your product.
§  Expand and diversify and grow:
·        Develop additional indications of the lead molecule.
·        Diversify via adjacencies, e.g., new formulations/analogs with better pharmaceutical properties of lead; attack same/related pathways as lead’s mechanism of action.
·        Forward integrate to the market.


Chapter 3: Platform Companies

Part I: Introduction: A Typology of Platform Companies

·        There are two genera of platform companies and, within the second genus, there are two species:
§  Genus (1) encompasses companies that pioneer novel therapeutic modalities and whose proprietary competitive edge lies in the ability to generate new and better products of that modality.
§  Species (A): Insights into pathways, targets, etc. and their relationship to disease.

Part II: Creating Value in a Genus 1 Product (Therapeutic Modality) Platform Company[2]

o   You need to drive as many shots on goal as possible.
o   You need to stay ahead of the pack in the perfection of your platform/product engine: be, continue to be, and be perceived as the leader.
  • Because you have a potential “embarrassment of riches,” you can partner early and often to raise non-equity capital because whatever product rights (= source of long-term value) you monetize, there will be more where those came from.
    • Early deals can give away all product rights, e.g., to a disease area, maintaining only a downstream economic interest (typically, milestones and royalties).
    • In the next step, the ability to “belly to the bar” for greater downstream financial participation (cost and profit share) will likely feature without commercialization rights.
    • In the following step, some level of commercialization rights (co-promotion/ geographic splits) will be added to the cost and profit share.
      • In a possible next chapter, the deals may add on full commercialization rights to one or more of the products coming from the collaboration (e.g., via a picking mechanism).
        • It is the author’s belief that you are better off sharing in all of the fruits of the collaboration with profit share and retention of a geography and/or co-promotion than in going with a picking mechanism to provide forward integration to commercialization ability. Picking is a binary bet…spread the risk.[3]
  • The combination of a high stream of non-equity capital and clarity that you are using that to build out the leading platform while, at the same time, you have retained enough opportunities for forward integration into downstream value, will drive your stock price up.
    • Now is the time to use the equity markets as your primary source of capital to fuel your retained product opportunities.[4]
  • Counterpoint: Why can’t a Genus 1 Product (Therapeutic Modality) Platform Company choose never to forward integrate and just remain a product engine for others who make and sell the end products, collecting high-margin royalties/profit shares?
    • The model here is “Intel Inside.”
    • In theory, the model makes sense.
    • In practice, there are only two companies I can think of in the history of the industry with a multi-billion dollar market cap that have done it, ISIS/Ionis and GenMab.
      • Even ISIS/Ionis has held onto some product rights and is, via a majority-owned subsidiary (Akcea), forward integrating into commercialization.
      • Moderna is the current version of the ISIS/Ionis model; here, too, it has held onto some product rights.
    • While in theory the “Intel Inside” model makes sense, the important differences between a computer chip and a drug suggest why the theory has a fundamental flaw.
      • It is not, or not simply, that the probability of success (POS) of making a drug, and then a second drug, is so much lower than the POS of making the Generation 1 chip and then a (significantly better) Generation 2 chip; and it is not, or not simply, that the time from idea to product is so much longer and more costly for a drug.
        • Assume, for the sake of argument, that the POSs, development times, and costs are the same for developing a chip and for going from a Generation 1 chip to a Generation 2 chip as it is to develop the first drug and then go on to develop the second drug.
      • The key difference is that the Generation 1 chip can be “inside” multiple different products in multiple different verticals; this is not the case for a drug.
    • So, Isis/Ionis and GenMab stand out as the exceptions to the rule.

Part III: Creating Value in a Genus 2 Novel and High-Value Insight Platform Company[5]

Species (A): Insights into pathways, targets, etc. and their relationship to disease

·        As with Genus 1 Product Platform Companies, in general if you are a Genus 2, Species A Platform Company: Novel and High-Value Insights (claiming insights into pathways, targets, etc. and their relationship to multiple diseases), your primary risk is under-spending/under-capitalizing early.
    • Your value is directly driven by your first-mover advantage.
o   You need to drive as many shots on goal as possible.
o   You need to stay ahead of the pack in the perfection of your platform/product engine: be, continue to be, and be perceived as the leader.
·        The partnering strategy employed for the Genus 1 Platform Company is exactly the same: partner broadly, increasingly forward integrate into rights/profit participation, and then forward integrate into proprietary product development.
·        HOWEVER, Genus 2, Species A Platform Companies face a set of challenges not faced by Genus 1 Platform Companies. These arise intrinsically from the fact that the output of the Genus 2, Species A Platform Companies is data/information/insights, NOT, as with the Genus 1 Platform Companies, New Chemical Entities (NCEs) and biologic therapeutics.
o   The history of data in the biopharmaceutical industry is the history of its commoditization.[6]
o   Companies whose “life’s blood” is drugs/products have a vested interest in rendering data “pre-competitive” (or, at least doing so after they have had proprietary access for a time). They win based on their products; they don’t want to be held captive by the owner of the information.
o   A more restrictive intellectual property (IP) environment: gone are the days when a transcriptional profile showing over-expression of a gene in a diseased tissue (or a genetic mutation in the diseased state) could get you an issued patent of the logical form, “a method of treating disease X comprising modulating target A by any means” (with dependent claims stating that the “means” could be an antibody, an antisense, an RNAi, a gene therapy, a small molecule, etc.).
o   Moreover, the demands of the customer base became more expansive over time. Whereas, in the 1990s, most big pharma customers were willing to agree to terms that restricted their use of the data to the discovery and development of small molecule drugs (because that is all they did), in the present all pharmas/big biotechs would demand the right to exploit the data for all therapeutic modalities.
o   Finally, the Genus 2, Species A Platform Company has and builds its expertise in the generation, curation, and interrogation of the data. It does not come into existence or can afford to cultivate/invest in significant capabilities in drug discovery/development in one or more therapeutic modalities, or in-depth biology/translational capabilities, in one or more diseases.
§  The Net Result: the Genus 2, Species A Platform Company ends up abandoning its data/information business to build and become a drug discovery and development business.[7]
·        Counterpoint: Why can’t a Genus 2, Species A Platform Company (novel and high-value insights) choose never to forward integrate and just remain an information company whose customers make and sell the end products, collecting high-margin royalties/profit shares and/or just selling the information at a high margin?
o   The model here would be, e.g., Bloomberg.[8]
o   But, now, consider the Bloomberg business model and the respects in which it differs. 
§  Time value of information: the bond or currency trader making multi-hundred million-dollar trades lives or dies based on moment-to-moment information. Last time I checked, the drug discoverer can wait a week (a month? six months?) for the latest genetic sequence or proteomic profile.
§  Value of that information: for the trader, that information, and its currency, is the key to making the investment which is the money-making activity. For the drug discoverer, the information is just the start of a multi-year, multi-disciplinary journey lasting a decade or more to the money-making activity (= discovery, development, approval, and marketing of the drug). Hence, a subscription model, not a royalty/profit-share model of payment, is the only one that will sell.
§  Number of high-paying customers: a Bloomberg terminal subscription costs $30,000/year per user (not per firm). In 2016, there were 325,000 terminals in use. How many pharma and biotech subscribers, in a best case, would there be at what user fee?
o   In at least one case, namely deCode, the information was of such a special, and potentially powerful, nature (the genetically homogenous population of Iceland plus the Icelandic national database of EHRs), that a single company, Amgen, saw enough value to purchase it for exclusive use.
o   23andMe is a deeply instructive, unfolding model well worth reflection.[9]

Species (B): Insights based on a deep, disease-specific biology and related translational research/medicine expertise

·        If you are a Genus 2, Species B Platform Company: Insights based on a deep, disease-specific biology and related translational research/medicine expertise, you face a potentially very challenging path with elements shared by the Genus 2, Species A Platform Companies but a tougher row to hoe.
·        On the one hand, your primary risk is under-spending/under-capitalizing early.
    • Your value is directly driven by your first-mover advantage with your (novel) insights into the disease: you need to invest.
§  You need to stay ahead of the pack in the perfection of your platform/ product engine: be, continue to be, and be perceived as the leader.
    • From very early on, you also need to invest in the drug discovery capabilities necessary to capitalize on your insights: you need to drive downstream of the insights.
    • However, equity markets will have trouble according you value without tangible drug candidates.
    • Hence, you need to partner early so as not to experience over-dilution early.
    • However, unlike the Genus 2, Species A Platform Company, you are not intrinsically able to partner broadly.
      • You can do a single-player, multiple-target deal, but it is very hard early on to take on multiple partners.
      • Therefore, pray that your biology is viewed as a “gotta have” by players in your disease space and that there is at least one player who is relatively price insensitive because of a significant strategic commitment to the area in which you are working.
    • If you secure a large, foundational corporate partnership, you will have to retain significant rights because you will not have anywhere near the number of shots on goal as the Genus 2, Species A Platform Company.[10]
      • This will often require “bellying to the bar” to help shoulder development costs.
    • So, you need to take the corporate partner dollars early while retaining significant rights, you need to execute, and, as candidates emerge which capital markets will value, you move into the equity raising mode, at higher prices.
o   With success, you can look to broaden your biological focus into adjacent areas that leverage the capabilities and expertise you have built.[11]


Epilogue: The Role of In-Licensing Product Candidates

The foregoing has systematically left to the side the role of in-licensing product candidates in early-stage biotech company value creation. We tend to think of in-licensing as the domain of big pharma, with biotechs doing, not buying novel discovery. In fact, in-licensing product candidates has played a major role in many, if not most, successful biotech companies. Here are some cursory thoughts on the matter.

·        For Product Companies, the product candidate that forms the basis of the company is, in fact, most often in-licensed, either in the fully blown form that is taken into the clinic or as the active pharmaceutical ingredient (API) (or near-final API) that with some tweaking or formulation for better pharmaceutical properties is taken into the clinic.
·        For a Genus 1 Product (Therapeutic Modality) Platform Company, product in-licensing is much less likely to feature, at least early in its history.
o   This is almost definitional as the company is pioneering the new therapeutic modality.[12]
o   Over time, as others begin to practice the new modality, product in-licensing will assume a more prominent role.[13]

·        For a Genus 2, Species A Platform Company: novel and high-value insights into pathways, targets, etc. and their relationship to disease in general, product in-licensing is less likely to feature early in the company’s history.
o   The fundamental thesis of the company is its ability to identify and elucidate the role in disease of new, previously undrugged targets/pathways; hence, any in-license will be in its nature serendipitous: an existing molecule, designed to modulate a different target/pathway or disease so happens to modulate the novel target/pathway.[14]
o   The company will have focused its resources on its platform and is unlikely to have invested in building the capabilities (e.g., non-clinical and clinical development) necessary to prosecute an in-licensed molecule.
o   Moreover, in the early stages, the fundamental value thesis is the platform. The presence of an in-licensed molecule can come to dominate the market’s perception of the company; the company becomes a binary bet with pressure to decrease investment in the platform in favor of investment in the in-licensed molecule.
§  Hence, if the full value of the platform is to be appreciated by the market, the company needs to work overtime to keep the market focused on the value of the platform.[15]
§  If/when the promise of the platform fails to be (fully) realized, product in-licensing can prove to be the difference between failure and success.[16]
·        For a Genus 2, Species B Platform Company: Insights based on a deep, disease-specific biology and related translational research/medicine expertise, product in-licensing is also less like to feature than in a Genus 1 Product Platform Company but more likely to occur than in a Genus 2, Species A Novel and High-Value Insight Platform Company.
o   The company will have some of the relevant capabilities/knowledge, in the form of in-depth, disease-specific biology and translational research, to enable it to prosecute the earlier stage of development of an in-licensed product candidate.
o   Nevertheless, as with the Genus 2, Species A Platform Companies, the company will have to work overtime to ensure that the market does not equate the company’s value with (the fate of) the in-licensed molecule.


Responses and Replies

JEFF TONG

Hi Steve,

Well thought out, as always.

I know this is a prelude to Decibel, so this example will take you somewhat on a tangent, but for completeness, Illumina arguably is the most successful pure-play “Platform” company in a long time (that also interestingly isn’t forward-integrating into therapeutics).

I’m sure it’s implicit, but I also think it’s worth explicitly pointing out that the financing/ capitalization strategy has to be intimately tied to the maturity and value creation curve of the science / platform / etc... and therefore one can only judge the risk of under- or over-capitalization as a function of how and on what the money would (or wouldn’t otherwise) be spent.

A graph that, for me, sums up the inter-connectedness of the two has always been the following:







HOW one gets to the ‘major value event’ makes a difference...while the company is the same market cap at the end, the share price can be dramatically different. And that’s a function of both the capital-raising strategy and the value-creation curve. On the former, Bruce Booth did a nice dissection of Juno vs. Kite showing the difference in capitalization strategies. Both incredible financial and scientific/clinical successes of course, but nonetheless still a material difference between the two outcomes (https://lifescivc.com/2018/01/two-carts-two-charts-dissecting-returns-t-cell-therapy-ma/).

Jeff


RESPONSE TO AND INTERCHANGE WITH TONG

HOLTZMAN

Thanks Jeff. I would suggest that Illumina is an equipment (and related reagents) company… they were never a “platform” company in the sense I defined these (re Genus A = therapeutic modality platform; Genus B = information/insights applicable to biology/disease per se [Species A] or specific disease biology [Species B]).

If drugs are the gold, then the companies of which I am speaking all end up as gold prospectors because their platforms become commoditized (particularly the Platform B companies). Illumina is Levi Strauss, selling the tools and jeans to the prospectors…and staying ahead of the competition by making better and better tools and supporting services (something Affymetrix failed to do).

Interesting question: both information and hardware become commoditized over time. So, how does one stay ahead in those games? And why is it that a hardware player (in the form of Illumina) has done so successfully while no information company in our industry has been able to do so. I think that comes back to number of users (= potential customers).

TONG

True - but there is indeed an example of an information company uniquely being worth something too: Foundation Medicine.



HOLTZMAN

With respect to Foundation: I believe that, in its initial incarnation, they saw themselves as a Genus 2 company, with potential for Species A (info for disease per se) but starting with a Species B (cancer) approach, that would sell high-value information to big pharmas (initial Roche deal). In this sense, they were like Myriad. However, again like Myriad, they morphed into a Diagnostic Service Business (by analogy, Illumina is a Research and Diagnostic Product Business). (In contrast, Genomic Health, right from the get-go, set out to be a Diagnostic Service Business…but Foundation ends up in the same place, and bought by a larger Diagnostic Service Company).

================================================

MARK LEVIN
Hey Steve and Jeff

I love this conversation!!

A couple added points. Mine will be much shorter than Steve’s and are inspired by my favorite philosopher Nitschke (as in Ray) who had a wonderful perspicacious insight into the biotech field.

POINT ONE
A company Steve, John, Kevin, and I know well, Millennium Pharma, raised $8.35M in VC dollars total at $1 per share/post $13M and sold for $100 per share/$9B (two 2x splits in company’s history).

A good case for raising a small amount of VC dollars and doing partnerships early on if you have a Broad Platform company with multiple opportunities.

If the VCs held on, they received a 100x on their investment at the sale of Millennium to Takeda. IPO investors at $12 a share (I think-$225M post) received an 8x if they held on to acquisition.

Millennium was hatched in the genomics craziness of the 1990s and was a platform company first, a few years later a target, then biology/disease company, and eventually a product company based on product company acquisitions. Although the VCs and IPO investors did well, many investors in the late 1990s did not do as well/actually poorly based on the value of the company rising to $19B during the genomics craziness.

Investors at $19B received a negative 50%+ return if they held on to sale. Post the crash in the early 2000s, the company’s value plummeted to approximately $2B or so. The investors who invested at this low point and held on to exit, received a 4x +.

Lot of great messages here
0)     If you can raise $8.25M in VC dollars total and complement with “non-dilutive” partnerships to get to public markets, you are off to a great start.
1)     Large Series A investments from the VC community are expensive and if done, need to be complemented with real value from the VCs. If you can start with a small investment and immediately complement with a major pharma (non-dilutive partnership), great strategy.
2)     Broad biotech platform companies with multiple disease applications in “revolutionary new areas” can form very substantial “non-dilutive” partnerships and raise money (debt and equity) at non-dilutive prices (GENOMICS, RNAi, GT, CRISPR, CART….).
3)     Teams that include Steve (Holtzman), John (Maraganore), Kevin (Starr), Bob (Tepper) and others are necessary to evolve/iterate/build early platform companies to targets, then diseases, then acquisitions ESPECIALLY when your platform is 15 years early, to ensure products in a reasonable timeframe.
4)     Use your stock price to acquire product-related/complementary assets when your value is disproportionally overvalued compared to others.
5)     Don’t invest in a $19B biotech company with one molecule in early-stage clinical trials; you are overpaying.
6)     Breakthrough products are key to REAL long-term value creation for the patient and the investor.

POINT TWO
This is where our VALUE CREATION MODEL came from at TRV and one we insist on following for all our companies in order to maximize value creation for patients and shareholders.

POINT THREE
Sticking to your investment model can be painful. We talked to Rick Klausner and the President of the Hutch almost a year before Juno was founded. We were asked to invest but passed.
They were going to raise $200M in Series A and we were concerned about the dilution/Value Creation Model.

Thanks Steve for your insights - I love it!!
mark

RESPONSE TO LEVIN

HOLTZMAN

First off Mark, it would appear that somewhere in the last decade you have learned how to unlock CAPS LOCK. (I guess that proves that, indeed, Nothing’s Impossible.)

As you imply, what became the “TRV Model”—a platform company which enters into one or more broad, “foundational” partnerships early in its existence—was grounded in your start-up experiences before and at Millennium. What I think is worth noting, and acknowledging as truly original, was that model when you initiated it at Millennium.[17]

The first generation biotechs (the recombinant protein companies) had broad product platforms that could have provided the basis for such broad foundational partnerships. However, what history shows is that they chose, instead, to partner product candidate by product candidate.[18] For example, a Genentech could have entered into a single, broad partnership with a diabetes company for all secreted proteins relevant to diabetes or a single agricultural health company for all secreted proteins potentially relevant to the area (e.g., bovine and porcine somatotropin, the bovine and porcine interferons, etc.).

Similarly, one of your earliest start-ups, Cell Genesys, developed the first genetically engineered mouse capable of generating fully human antibodies, and established a broad patent position on the technology covering any such mammal produced through germline homologous recombination as well as any (human) antibody generated by such a mammal.[19] Cell Genesys (Abgenix) could have entered into a broad foundational partnership, either covering all antigens/hMAbs relevant to a disease area[20] but did not, instead doing antigen/product by antigen/product deals while forward integrating on a specific product of its own, namely a hMAb directed to EGFR.[21] In the event, it did not.

What I would argue was your second radical innovation at Millennium was broad foundational partnerships based not on (potential) products but on novel biological insights (targets). In other words, Millennium was not a Genus 1 Product Platform Company; it was an extremely broad—and arguably the first—Genus 2, Species A Platform Company. Its “disease-by-disease” large-scale partnering model was (at least to me) interesting for helping to elucidate a distinction that gets lost in speaking about the “genomics” revolution of the 1990s and the companies from that era.

There were in fact two distinct classes of “genomics” companies.

The first comprised the large-scale sequencing companies (e.g., HGS and Incyte). For them, “genomics” meant high-throughput DNA sequencing. The outputs of sequencing (= the genes), through new bioinformatic techniques, could be grouped according to biochemical class, e.g., GPCRs, ion channels, enzymes; however, sequencing in and of itself provided no disease annotation.

The second class comprised the large-scale genetics companies (e.g., Millennium, Sequana, and Myriad [with deCODE following a few years later]). Genetics, of course, starts with a phenotype (such as a disease phenotype). The genetics companies then used the new large-scale technologies to isolate in the genome (what was called “positional cloning”) the gene or genes that were responsible for, or contributed to, the disease phenotype.

Thus, for Millennium, “genomics” was not, or not simply, high-throughput DNA sequencing. We came to define genomics very broadly as the application of high-throughput process technologies (robotics), micro-miniaturization (microfluidics), and the advanced information sciences to the elucidation of biology. Hence, beyond large-scale sequencing and SNP analysis,[22] Millennium also implemented large-scale transcriptional profiling and large-scale proteomic analysis in the context of specific disease-area programs.[23] It also meant that Millennium built up multiple disease biology groups in areas such as diabetes, obesity, immunology, cardiovascular, oncology, and CNS. It was this combination of technologies and expertise in multiple diseases that enabled Millennium to enter into its string of multiple, large disease-area alliances, a partnering approach not available to the large-scale sequencing genomics companies.

That said, since large-scale sequencing featured among the “genomics” technologies put in place by Millennium, by 1997 this provided the basis for Millennium to establish large alliances that were not based on a disease area. Thus, Millennium established a subsidiary, Millennium BioTherapeutics,[24] which had the rights to exploit genes encoding proteins elaborated on the cell surface to develop therapeutics comprising secreted protein and MAbs. “MBio” entered into a foundational alliance with Eli Lilly to share the output of these efforts.[25] The parent company, Millennium, retained the right to exploit all other (biochemically classed) genes that came from MBio’s sequencing efforts.

The establishment of that massive-scale sequencing capability for MBio (with half the funding provided by Lilly) and the sequence database it generated, then enabled Millennium to enter into two large, seminal, “second-generation” alliances. The first, also in 1997, was with Monsanto. Monsanto was in the initial phase of buying up seed companies for all of the major crops. Germline “gene therapy” is the heart and soul of plant genetic engineering. Monsanto needed to rapidly sequence the genomes of all of the major crops in order to not be pre-empted by its competitors. The fastest way to do this was, effectively, to enlist Millennium to do it for them. However, Millennium decided that it did not want to get into the agricultural arena, even via a subsidiary. So, instead, Monsanto established, literally next door to Millennium, a wholly owned research subsidiary (Cereon) to which Millennium transferred its sequencing and bioinformatics technologies for exclusive use in the field of agriculture.

The sequence database generated by MBio, and Millennium’s retained right to use the database for drugs other than secreted proteins and MAbs, then enabled (in 1998) the large alliance with Bayer. In this alliance, Millennium provided to Bayer (hundreds of) potential targets for small-molecule drug intervention defined by biochemical class (e.g., GPCRs, intracellular enzymes, and ion channels).

Why do I recite this history of Millennium first- and second-generation partnerships, particularly to you who lived and led the company?[26] I do so because I fear that in speaking of “The TRV Model” (based in “The Millennium Model”), too many current generation start-up biotech leaders (and their venture backers) fail to appreciate the subtlety and art necessary to practice “the Model”; as it were, they think it is rote. In reality, using large partnerships to create out-size value requires a keen sense of the external partnering environment, identifying the potential partner(s) which at that specific moment in its/their history has/have come to perceive a critical need for what you have, and crafting deals in which you, while you sell rights, retain the potential for value creation by, for example, retaining ownership of the knowledge. That, not a cookie-cutter model, is your legacy in this arena.[27]


==============================================


From John Maraganore
From: John Maraganore <jmaraganore@alnylam.com>
Sent: Tuesday, July 3, 2018 6:10 AM

All,

Great comments from Mark and Jeff and, as always, great insights and framing from Steve. (Steve- I still regard your funding scheme slide that you shared with me 15 years ago as the “bible” of biotech capitalization!)

I would just add the following points:

For the product platform approach, I’m very biased.... but the greatest value creation requires significant product rights retention. I agree that an effective way to fund is with partnerships that involve either geographic splits or profit sharing. However, it’s critical that the platform value is adequately recognized by the partner (e.g., SNY-REGN) to obtain the right economics and governance. Indeed, the greatest downside is loss of full control, which is an extremely expensive cost (sometimes priceless)! Alternatively, financing the company with a robust equity market and retaining full and global control of assets can be a vastly preferable approach, but does require an efficient product development/commercialization strategy such as rare diseases. Regarding the “Intel Inside” strategy, I’ve soured greatly on that approach over the years. It leaves a ton of value “on the table,” as best represented by the relative valuations (and share prices) of IONS and ALNY. –Just my $0.02

RESPONSE TO MARAGANORE

First, at least in my book, with what you have accomplished at Alnylam, you have proven to be the single greatest student and practitioner of the model.[28] How you have used partnerships to build Alnylam and, in particular, the evolution of your partnership structures, I find to be deeply instructive.

An important evolution in the history of the pharmaceutical industry was occurring shortly before the launch of Alnylam, a change which you recognized and capitalized on to the max. Leaders of big pharma, which were prototypically small-molecule chemistry companies, were recognizing that they had largely “missed the boat” on protein therapeutics and MAbs, which were now becoming billion-dollar drugs. As it were, swearing that they would never let this happen again, they sought to ensure that they would never be squeezed out of, and would make sure to get an early foot in the door on, any newly emerging therapeutic modality. At that moment in history, RNAi was just coming on the scene. The latent demand existed for Alnylam as the first mover to corner the market.

Unlike in the early days of recombinant proteins and MAbs, where the practice of the technologies required significant proprietary know-how, once published, RNAi was fairly straight forward to master. Therefore, the key for Alnylam was to broadly capture ALL of the relevant IP, effectively gaining patent coverage on any/all RNAi drugs. You rapidly achieved this goal. The net result: big pharma had to “come through” Alnylam if it was not to risk being squeezed out of the modality.[29]

This, I would argue, is what allowed Alnylam to establish its foundational deals with Novartis and then Merck.[30] These partnerships, which featured very large, up-front and near-term non-contingent funding, enabled Alnylam to cement its first-mover advantage.[31] They were the ladders you climbed from the dark cave (= negative cashflow) of start-up and then kicked away as you emerged into the sunlight of forward integration into proprietary product development.[32]

Since those early foundational deals, Alnylam has masterfully intertwined the art of combining raising equity dollars when capital markets are favorable with entering partnerships with increasing retained product rights.

With the recent approval of its first product (big congratulations), the challenge in front of Alnylam for the next several years is not to have its value equated with the DCF of the first product or two and/or EPS growth. What will power Alnylam into a future of truly out-sized value creation and sustainable independence is the renewable pipeline of more and more products. In your words John: “don’t turn the corner too soon.”

PS: Thanks for remembering the slide (which was jointly created with Jeff Tong) from lo those many years ago. For a stroll down memory lane, it is reproduced below.





======================================

Responses and Replies: Round 2
Jeff Tong
A few additional thoughts
“Intel Inside” companies-- I think Medarex and Abgenix are worth mentions here. That technology is now embedded today in multiple commercial products, and the productivity of the platform (+ the value of their own internal pipelines at the time) ultimately led to their acquisitions. An interesting case study in value creation - had Medarex not been acquired, what would it be worth today? (they contributed BMS’s anti-CTLA4 and PD1 programs). In contrast, had Abgenix fully played out the Vectibix story, it might have gone the other way (not a commercially successful, big product). At the end of the day, it’s still breakthrough medicines that drive the realization of long-term breakthrough value. But there are ups/downs along the way where many companies will exit along the way. And of course, public shareholders can enter/exit anywhere during the ride too by simply buying or selling shares. And conversely, what would BMS look like today w/out Medarex? Would it even still be independent? And Takeda without the Velcade/proteasome franchise & Entyvio?


Holtzman

In my response to Mark, I do discuss the Abgenix case (re: initially “Intel Inside” in the Japan Tobacco deal, followed by forward integration of Vectibix leading to the Amgen acquisition). I didn’t mention Medarex (albeit, I did note in passing its European spin-off, Genmab), the latter of which has arguably been an even more successful example of the “Intel Inside” strategy than Isis/Ionis.[33]

Tong

Your Footnote 11: Yes, many things had to go Agios’s way. One additional one that is important is that Celgene returned the rights to AG-120 (IDH1) after paying for nearly all of its development. This now provides Agios a fully owned product for which it has submitted an NDA many years before it would have otherwise been able to get to with its non-Celgene pipeline.

Holtzman

A picking mechanism that worked in the small company’s favor by being abrogated…

Tong

Footnotes 15/16: of interest, the acquisition of Leukosite actually had two unexpected fruits. The first of course was Velcade which Millennium enjoyed. The second turns out to be Entyvio which Takeda (post-Millennium acquisition) is now enjoying.

Holtzman

Another interesting tale.[34]

===================================

Levin

Hey Steve

I will never forget a couple interesting moments that fits into an overall comment I will make.  When we were negotiating with Wyeth to hold onto significant rights in the CNS area, we were in your office late one night doing an NPV calculation on the project. We, of course, came up with a very significant NPV - very negative. And the next day, went back to Wyeth and changed our strategy so we could use their dollars (not the rights) to maximize more valuable programs.

A few years later, we did a detailed NPV model around our entire Millennium pipeline along with a Monte Carlo analysis on likely pipeline scenarios over a 10 yr period. All scenarios indicated unlikely products in the next decade. Yet, our public value was extremely high. This discussion was key in launching our product acquisitions efforts ASAP.

NPVs on early stage companies, of course, are flawed yet at their highest level, integrated with Informed Monte Carlo analysis and practical R and D input, can give critical strategic input into BD and an overall company strategy.

So, my overall point, when building a Product Platform Company, a company should put in place an Overall Value Creation Model Pipeline tied to NPV of the Pipeline, tied to financial requirements, tied to BD strategy (know what hold, know what to deal, and for what value) and financing strategy in order to maximize value to patient and share price.

Always remember it is only a model and is only as good as the input, but using the input as a key tool in the overall gestalt of things will drive better decisions


HOLTZMAN

On NPV Analysis: You’ve all previously read my view on the role of NPV, etc. analysis for decision making; see, “ON NPV, DCF and IIR(ELEVANCE)”, BioCentury, September 26, 2016, and also available on this blog: https://leadershipandbiotechnology.blogspot.com/.

--It is fascinating to me that the majority of comments I got on this piece from industry colleagues focused on the first half of the article (re: the proposed alternative financial analysis of RU, RD, and WIYD) and also on the question of the cost of capital to the rich and poor man when playing the lottery. To me, the much more interesting set of reflections, the ones that provide the most food for thought, begin on page 2 with, “The Moral of the Story” where I address the dichotomy between a career vs. a vocation and a cast of mine that seeks a refuge from responsibility in the illusion that human action can be dictated by mathematical/logical analysis. --By the way, with respect to the quote from the piece that BioCentury chose as the headline pull-quote [“We are tricked into confusing the extraordinary precision of financial analysis with accuracy.”]: Dr. Tong, while you were in constant discussion about such things from 2001-2009 (and pretty much ever since, on reflection, it was you not I who coined this pithy summation…belated apologies for my lack of attribution to you in that article.

On That Night in My Office: for John and Jeff: we had, in rapid succession (early-1994 through mid-1996), knocked off partnerships with Roche (Diabetes/Obesity), Lilly (Oncology), Astra (Asthma), and Lilly (Cardiovascular), and had gone public. We were negotiating with Wyeth (CNS) and the question was whether to replicate the earlier deals (they fully funded discovery, they get the targets for small molecule discovery [with us getting royalties], and we retained the protein, MAb, antisense, and diagnostic rights) or, instead, it was time for us to “belly to the bar,” assuming more of the costs/risks of early discovery in exchange for more rights/a bigger piece of the action. We had postured this to Wyeth and, after much consternation, they agreed to it. In the “Oh shit!” moment Mark describes, Levin and Holtzman (aka the blind leading the blind) stood at a whiteboard doing the NPVs that Mark describes that led us to conclude that Millennium had not yet reached a point in its evolution where we could/should take on that risk. –So, I got on a plane the next day to Philly with my tail between my legs begging to return to the original deal structure. (Note: a year later, via the MBio subsidiary and its foundational deal with Lilly, we then did start “bellying to the bar” for half the costs of discovery [albeit, the cash to do so came from Lilly’s equity dollars for 20% of the sub].)

Other ground-breaking conclusions Mark and I reached that night:

 * never take equity dollars: they are always dilutive
 * never take debt: you always have to pay it back
 * never sell away rights: they are the source of your long-term value
 * never use your own money for early R&D: it is too risky and NPV negative

–From this we derived the “Gift Model” of Early Biotech Financing: find someone willing to give you large gifts of money with no strings attached: no stock, no repayment, no marketing/ profit participation rights. Arguably, that model has come to pass in three forms: (1) what I earlier called the “Rent a Program Model” (develop the program in a partnership using the partner’s money and then get it back for free when a new head of R&D takes over at the partner and orphans your program in his need to establish an identity in opposition to his predecessor; (2) the Gates Foundation; and, (3) “dumb money”, invested at ridiculous valuations in overheated equity markets.

More seriously, this goes to the whole issue of how you sequence the deals, or more accurately the nature of the deals that you do as your company evolves and the interplay of the same with equity…which is really what this whole dialogue has been about.



[1] Paradigm (“successful”) product companies would include Cougar, Medivation, Pharmasett, Pharmacyclics, and (in process) Sage and Intarcia. Note: the overwhelming majority end up being sold as, essentially, single-asset plays.

[2] Paradigm novel therapeutic modality platform companies would include the pioneers in rDNA technology for therapeutic proteins (Genentech, Biogen, Amgen, G.I.), the antibody companies (Centocor, Abgenix, Regeneron, Adimab), biologics from genomics (HGS, MBio, G.I. [discoverese], 5 Prime), antisense (ISIS/Ionis, Hybridon, Gilead [in its initial incarnation]), mRNA (Moderna), gene therapy (Generation 1: Cell Genesys, Somatics, GenVEC, GTI; Generation 2: Bluebird, RegenX, Uniqure), CAR-T (Juno), and CRISPR (Editas). (The companies that produced, at scale, the first-generation kinase inhibitors (Vertex [Novartis relationship] and Exelixis [GSK relationship]) are a variation on this.)

[3] Offhand, the author cannot think of any company of this type that “won” via a picking mechanism. On the other hand, Genentech (Roche), Amgen (Kirin), and Regeneron (Sanofi) have done just fine sharing all and splitting by geography.

[4] It is worth noting that, in the 1980s/early 1990s, the first-generation biotech companies had available to them alternative financing vehicles. Initially, these took the form of R&D Limited Partnerships, imported to the biotech industry from the world of gas and oil exploration by Bob Swanson (founding CEO) and Tom Kiley (founding GC and VP Corporate Development) of Genentech, that were heavily used by Genentech, Centocor, and others. These disappeared when part of the Tax Reform Act of 1986 eliminated the R&D tax credit. The next incarnation of the alternative, off-balance sheet vehicle was the special-purpose entities (with names such as SWORDs and SPARCs), invented by Stelios Papadopoulos and his crew at Paine Webber Development Corp, and heavily exploited by G.I., Centocor, Genzyme, and others. These financing vehicles allowed the companies to maintain and finance their product candidates with less dilutive equity-like dollars. In every case I can think of, when the product developed using the alternative financing was successful, the rights to the product were reacquired with shares in the “parent”; however, in virtue of the success of the product, the equity had appreciated significantly in value. As it were, equity was raised “today” at “tomorrow’s” higher, and thus less dilutive, share price.

[5] Paradigm Novel and High-Value Insight Platform Companies, Species A (insights into pathways, targets, etc. and their relationship to disease) would include the first-generation, large-scale genetics/genomics companies (Millennium, HGS, Incyte, and Celera). Variations on this theme are (or will prove to be) the new generation of “big data” plays (e.g., a database of the single-cell, RNA Seq profiles of every cell, under every possible condition; a database of proteomically defined pathways; the “cancer atlas”; etc.). 23andMe is a variation (and an instructive variation); see discussion below.

Paradigm Novel and High-Value Insight Platform Companies, Species B (insights based on a deep, disease-specific biology and related translational research/medicine expertise) would include the early CNS companies (Athena, Cambridge Neuroscience, Cephalon, Regeneron [in its first generation as a neurotrophic growth factor company]); a more recent example would be Agios (aberrant metabolism of the cancer cell); more recently still, Tango (synthetic lethality in cancer).

[6] For example, no sooner were the initial genetics/genomics companies (HGS, Incyte, Millennium) off and running than big pharma, led by Merck, formed a sequencing consortium. Similarly, NIH massively increased funding of the Human Genome Project to ward off the emerging threat of Venter/Celera. In the current period, Regeneron and GSK have formed a “syndicate” with other companies to fund sequencing the UK BioBank.

[7] Hence, HGS becomes Benlysta; Millennium becomes Velcade; Incyte hires Paul Friedman and become a small molecule, cancer, and immunology drug discovery/development company; Celera buys Axys (Mike Venuti) to become a small molecule drug discovery company.

[8] Indeed, Celera described itself as “The Bloomberg of Biotechnology.”

[9] 23andMe charges $100 (low price) to the consumer (large potential market) for its data. At, say, 5 million users (a number they have yet to attain), it is a $500 million/year revenue business, not a high-margin, multi-billion dollar biopharmaceutical company. Interestingly, 23andMe fueled its growth by adding their ancestry business: people (other than Trump supporters) like to know where they are from/their geographical/ethnic heritage, how Neanderthal they are, who their relatives are, etc. In this realm, 23andMe faces emerging competition (e.g., Ancestry.com) in what will prove to be a race to the bottom featuring falling prices and increasing (expensive) direct-to-consumer TV advertising. Nevertheless, from what I can tell, 23andMe sees this “consumer” business as a means to an end. That end is the “resale” of the genetic data, combined with phenotypic information (and the ability to recontact its customers to collect more phenotypic information), to the biopharma industry for drug discovery/development purposes. In other words, they are pursuing the business model of the early genetics/genomics company. Until the recent large deal with GSK (July 2018) I would have said that that business is not flourishing: very few biopharmas had been willing to pay the high prices (including downstream participation) being sought by 23andMe. And, interestingly, following the pattern set by the early genomics companies, we have seen 23andMe forward integrate into proprietary drug discovery. In March 2015, 23andMe announced the appointment of Richard Scheller (former head of discovery at Genentech) as CSO and head of their new proprietary drug discovery unit. -- Plus ça change, plus c’est la même chose.

Whither the new, emerging generation of “big data/AI/machine learning biotech” plays? —This story is still being written. Having a different ending than its predecessors will, I believe, be a function of whether a step change in computational power is occurring that transforms the key value driver of drug discovery and development from science plus art to technology plus engineering/computation. While the liberal-artsy in me screams that this day will arrive on the same day that computers write Shakespeare, as a self-aware technological Luddite, I know what I don’t know; hence, I make no prediction.

[10] As advised earlier, use a picking mechanism at your peril.

[11] The “poster child” Genus 2 Species B Platform Company  in the last decade is Agios which has, for the most part, successfully implemented the strategy. It is useful to see how many things had to break Agios’ way to achieve what it has. First, Celgene was in a very special period, and played a very important role, in the ecosystem of young cancer biology companies, of which Agios was the prime example. Second, when the first projects/biological approach at Agios failed, it had the great fortune to have on the team the company’s founder, Michael Su, who is an extraordinary leader and drug hunter. He identified the new biology for the company (IDH) and then drove the initial product discovery/ development programs. Next, the first two drugs, both now approved, emerged from the first high-throughput screens in the first three runs, featuring good potency, selectivity, and pharmaceutical properties. They had a world-class drug discover chemistry lead (Janeta Popovici-Muller) who made the molecules into drugs (and eventually medicines) and drove the program team. Finally, though saddled with a picking mechanism, they managed to get Celgene to give them an early pick.

[12] Paradigm examples: Genentech, Biogen, and Genetics Institute (recombinant proteins); Centocor (MAbs); ISIS/Ionis (antisense); Genetic Therapy Inc., Cell Genesis, Merlin, and Somatix (first-generation gene therapy companies; Alnylam (RNAi); and Editas and Intellia (CRISPR).

[13] This is most obvious in the case of the first-generation, recombinant protein/antibody companies. For example, Genentech and Biogen’s marketed products and pipelines today feature many that were in-licensed. However, the phenomenon also can be seen in the new wave of gene therapy companies. Precisely because the Therapeutic Modality is not fully “novel,” there are product candidates—in other companies or the academy—available for in-licensing. Examples include Voyager (Genzyme’s Parkinson’s program) and Spark (UPenn’s RP program).

[14] A caveat: some newer platform companies of this type (e.g., CAMP4, which is elucidating genetically implicated pathways with novel disease associations) explicitly are seeking to in-license existing product candidates for “re-purposing.”

[15] The obvious example of this was the dilemma faced by Millennium when it acquired Leukosite in late 1999. Leukosite brought with it CAMPATH for the treatment of CLL which was approaching submission for approval. Millennium could not afford to let its value be viewed through the lens of CAMPATH as: (1) its approval, or failure to be approved, was a binary event; and (2) the product was projected to be a “small” product, which alone could never justify Millennium’s valuation. Hence, Millennium downplayed CAMPATH as a product and, instead, encouraged the market to see the acquisition of Leukosite as an acquisition of clinical development capabilities which Millennium would need as it began to forward integrate with the products that would soon be emerging from its platform. This strategy proved successful. In the immediately ensuing genomics bubble of 2000, Millennium was able to maintain its reputation as the leading genomics (not CAMPATH) company and, in the course of that year, completed two stock offerings which, together, raised ~$1 billion.

[16] Millennium again provides the paradigm case, albeit somewhat serendipitously. The acquisition of Leukosite with CAMPATH (described in the preceding note), also brought with it “PS-341,” a molecule which Leukosite itself had come into 3 months before via its acquisition of ProScript. PS-341 played essentially NO role in the Leukosite acquisition. In fact, the molecule was almost designated for the chopping block because there was little faith that an inhibitor of the (biologically fundamental and ubiquitous) proteasome could have a meaningful therapeutic index without deleterious side effects; and, furthermore, that a molecule featuring a boronic acid (the active ingredient in rat poison) would survive tox. In the event, Julian Adams refused to let PS-341 die until leadership became supportive. PS-341, of course, has come to be known as “Velcade.”

[17] In fairness, in the same timeframe (1993/1994), HGS implemented a similar strategy with its large, foundational SmithKline partnership.

[18] Or a couple of products at most; see Amgen-Kirin which encompassed both EPO and GCSF.

[19] Of course, the technology was spun off into a subsidiary, Abgenix…which, in the passage of time, became much more valuable than its parent.

[20] In one sense it did, albeit by geography, via its broad deal with Japan Tobacco.

[21] Which came to define Abgenix (see the main text for the challenge for a platform company of not becoming defined by its first product) and was essentially the sole basis of its acquisition by Amgen.

[22] The community did not yet have SNPs (much less whole genome sequencing); so, the positional markers used to map the loci of “disease genes” were (known as) “micro-satellites.”

[23] Since there were not yet commercial suppliers of transcriptional profiling and proteomic technologies (e.g., Affymetrix was just getting off the ground), Millennium had to develop these technologies itself. (This led to the interesting business challenge, by the company’s third anniversary, of financing an annual CAPEX budget of $50 million/year.)

[24] To which we recruited two extraordinary young leaders: John Maraganore and Kevin Starr.

[25] Which, to my knowledge, was the first deal featuring a “picking” mechanism. Not surprisingly, given that Maraganore and Starr are wheeler-dealers of the first order, MBio began trading with Lilly its “draft picks” for future proteins to be named later in the draft…

[26] Note: I have left out the formation of Millennium’s other spin-out, Millennium Predictive Medicine—which exploited Millennium’s retained rights to use all of the technologies and information generated in all of its alliances in the field of pharmacogenetics, pharmacogenomics, and diagnostics (and entered into major alliances with Becton Dickinson, BMS, and Roche). I have also left out the third-generation alliances in immunology (with Aventis) and diabetes and obesity (with Abbott), which were based on the earlier alliances (with Astra and Roche, respectively) in these areas which, by 1999/2000, had expired. –The biotech business model of “rent a program” is, to my mind, underappreciated.

[27] I can’t tell you how many brilliant 28-year-old MD/PhD and first-time company CEOs have offered to educate me on the critical need for start-ups to do a “Celgene-Agios deal.”

Since you started your response by citing your favorite philosopher, Ray Nitschke, PhD Linebacking, University of Green Bay, in this context let me leave you with a relevant quote from his German cousin, Friedrich Nietzsche, PhD Philology, Universities of Leipzig and Basel: “One repays a teacher badly if one always remains nothing but a pupil.” –Thus Spake Zarathustra

[28] Among the other first- or second-generation lineal descendants of Mark Levin who proved to be masters, my list includes: Laurence Reid (major deals at Millennium Predictive Medicine with Becton Dickinson, BMS, and Roche, and Maraganore’s partner in crime for a number of the Alnylam partnerships); Kerry Reinertsen (Laurence’s partner on those Millennium Predictive Medicine deals and leadership of subsequent major deals for Regeneron); Alan Crane (key leadership role on Millennium’s deals with Monsanto, Bayer, Aventis, and Abbott); Jeff Tong (key leadership role on Infinity’s major deals with MedImmune and Purdue/Mundipharma and, most recently, launch of Ambys with blow-away, foundational Takeda deal); and John Evans (key role in Infinity-MedImmune alliance and leadership of Agios-Celgene partnership).

[29] Lost in the history of our industry is the fact that in the late 1980s/early 1990s, there was one head of R&D in big pharma, namely Max Link at Sandoz, who saw the future importance of the emerging new modalities. He took Sandoz into major early deals with acquisitions of pioneer companies in the fields of gene therapy, antisense, cellular therapy, and xenotransplantation. A key reason for his early move into these areas was Sandoz’s leading role and, effectively sole pharma presence in the field of organ transplantation via Sandimmune (cyclosporine). In a similar, but much less expansive and visionary way, Baxter’s move into xenotransplantation, via its acquisition of DNX’s xenotransplantation program (to form Nextran), was motivated by its presence in renal/peritoneal dialysis and the potential for the disruptive impact of genetically engineered pig kidneys for xenotransplantation.) In the event, Link has proven correct, albeit some 30-40 years early.

Moving to the current day, big pharma/big biotech’s imperative not to find itself squeezed out of an emerging, new therapeutic modality is recapitulated and manifest in the large deals done with the (newer generation of) gene therapy, CAR-T, and gene editing (e.g., CRISPR) companies.

[30] That foundational deal with Merck should not be confused with the subsequent deal with Merck in which Alnylam purchased Sirna.

[31] At the time of the announcement of the Novartis deal, Alnylam made much of the fact that there was a “picking mechanism” and that, therefore, it had retained significant product rights for future value creation: Alnylam wasn’t merely doing contract research for potential downstream milestone and single-digit royalties. In fact, however, this was, I would argue, largely optics for the capital markets. While, to my knowledge, Alnylam has never disclosed the mechanics of the Novartis dea- picking mechanism, it was nowhere near what MBio had with Lilly (alternating picks from the get go). Depending on with whom you speak, Novartis had somewhere between the first 15 and 40 draft picks…so much for Alnylam’s retained product rights. (To which, Maraganore could reply, “See, NFL, 2000 Draft, Pick 199”.)

[32] If curious, to unpack this sentence, see Wittgenstein, Tractatus Logico-Philosophicus, Proposition 6.54 (The Wittgensteinian Ladder) and Plato, The Republic, Book VII (The Allegory of the Cave).

[33] Following the histories and fates of the first generation, pioneer transgenic animal companies (which, among other things, developed genetically engineered mice capable of producing fully human antibodies) is quite instructive. The first transgenic animal company, DNX (initially known as Embryogen) got off the ground in 1985/86. The next two, both formed in late-1987, were Cell Genesys (which eventually spun off Abgenix) and GenPharm. DNX was “low profile,” initially funded with < $500,000 by an angel investor with a 32-year-old first-time President. Cell Genesys and GenPharm were high-profile start-ups featuring backing from all-star biotech VCs (e.g., Mayfield, Kleiner Perkins, and Avalon) and featured a number of Genentech alums in senior management positions. All three companies had programs to develop transgenic mice with “human immune systems” capable of generating fully human MAbs. DNX called its mouse the HuMab Mouse (never trademarked, see below). DNX’s approach involved dissecting out from human chromosome spreads the three chromosomal regions encoding the heavy and light chains and introducing these into mouse zygotes via pronuclear microinjection. Had the approach worked it would have produced a mouse with a human immune system in one fell swoop. –Thousands of chromosomes and zygotes later, with no success, DNX dropped the program.

In contrast, Cell Genesys’ Xenomouse and GenPharm’s HuMab Mouse (it was never clear whether they simply copied the name from DNX or they happened upon the same name independently), were created by the more laborious approach of homologous recombination employing Bacterial Artificial Chromosomes (BACs) to deliver fragments of the coding regions. Since a BAC could only deliver a portion of the relevant loci, this meant that multiple mouse lines had to be established together carrying all the relevant genes and then backcrossed over multiple generations to get to a single mouse (line) carrying the entire repertoire. –In this case, the (two) tortoise(s) beat the hare.

DNX went on to establish two business lines: the first, through the acquisition of pre-clinical pharmacology/toxicology, provided services to pharma/biotech companies including drug testing in novel transgenic animal models of human disease (e.g., transgenic mice with human cholesterol profiles) and a transgenic animal production service. The second business continued in the tradition of the HuMAb mouse effort to use transgenic animals to generate homegrown pharmaceuticals, re: transgenic pigs with recombinant human hemoglobin for use as an acellular oxygen carrier (aka blood substitute) and transgenic pigs with organs that could be used for xenotransplantation to humans without immunological rejection. DNX went public in 1991 but by mid-1993 it became evident that its stable but low-revenue (~ $30 million/year)/low-margin testing business and cash-burning, high-risk transgenic pig program were incompatible. The pig programs were sold to Baxter in early-1994 where the xenotransplantation program made great progress until, a few years later, it was stopped in its tracks with the discovery of porcine retroviruses (a total show-stopper coming not that many years in the wake of the HIV epidemic). The testing business was eventually sold to a CRO with the transgenic animal production service subsequently being further sold to Xenogen…and then finding its final resting home at Taconic Farms.

Cell Genesys went public in early 1993. However, by 1996, it spun out Abgenix with the Xenomouse technology in order to focus on its gene therapy and cancer vaccine programs. As noted, Abgenix deployed the technology internally to develop Vectibix which then became the focus of the company leading to its acquisition by Amgen in 2006 for ~ $2.2 billion. Cell Genesys, with serial failures in its retained programs, went through many mergers/ acquisitions eventually being sold to BioSante in 2009 for $38 million.

With respect to GenPharm, as it so happened GenPharm and Cell Genesys shared a scientific consultant. Shortly after GenPharm filed with the SEC to go public in 1994, Cell Genesys slapped it with a lawsuit for trade secret theft and the filing of patents based on the stolen technology. The litigation overhang killed GenPharm’s IPO. GenPharm countersued for damages. While eventually (1997) it won a settlement of $15 million from Cell Genesys/Abgenix, it was a pyrrhic victory. On the verge of bankruptcy, the company was sold to Medarex later that year for $65 million. Medarex then went on to pursue an “Intel Inside” model entering into multiple corporate partnerships to generate fully human MAbs for their partners, including its work for BMS that resulted in PD-1 and CTLA4 products and BMS’ purchase of Medarex in 2009 for >$2 billion. In 1999, Medarex established a European affiliate, GenMab, that also pursued the Intel Inside model with multiple partnerships,.with royalties. Today, with royalties from Arzerra (marketed by GSK) and Darzalex (marketed by J&J), GenMab stands as probably the most successful “Intel Inside” model company with a market cap of ~$10 billion.

And then another young biotech company came along in the early/mid 1990s with a “better” mouse. It deployed it early on in the Intel Inside model as a source of current revenues, but it also used it internally to develop its own proprietary products. –That company goes by the name Regeneron…

---Bonus points to the reader who can name at least 4 rock bands, other than Crosby, Still, Nash and Young, that resulted from the backcross of The Buffalo Springfield X The Birds. Extra bonus points if you are under 40 years old (excluding my son Bryan for whom this music was the lullabies to which I played him to sleep).

[34] As Levin and Maraganore will attest, while Millennium accorded zero value to LKST-341 (Velcade), it did have interest in LKST-02. However, the molecule was in a very early stage, was hung up and going sideways in an unproductive partnership with Genentech, and was being produced in a cell line that was going to have to be rederived, sending the (newly produced) antibody back into pre-clinical studies. Nevertheless, the program refused to die, the partnership with Genentech was terminated, the new cell line and antibody were generated, and in 2014 (14+ years after the Leukosite acquisition by Millennium and 6 years after Takeda’s acquisition of Millennium), the molecule formerly known as LKST-02 was approved by the FDA and brought to market by Takeda as Entyvio…

Comments

  1. Little did I know when I accepted the job at Millennium 23 years ago I would have the opportunity to learn from the best! I remember these deals and discussions like it was yesterday. I still carry many of the lessons with me today. Great read Steve!

    ReplyDelete
    Replies
    1. thanks to this firm It is not advisable to just embrace every trade opportunity because of scam,i have been a victim and lost upto $28,875 USD trust me. It is always good to trade with broker using a transparent pricing, fast and reliable trade executions.. I have been scammed in forex and binary options before I got to know and actually recovered my funds back with the help of him,E-mail: globalhackingcompany@ gmail.com or WhatsApp +1(929)390-8581 hacker group and still went ahead to trade with them
      using their forex and binary options group an it has been lucrative ever since.
      They are advanced trading platform designed for active traders
      because of their clear, reliable pricing and superior trade execution.They have shown to be market leader with a proven record of strength and stability.
      Gains will vary based on market conditions, including volatility, available liquidity, and other factors.
      You repair your credit score with them and can also use them for any hacking services whatsoever..
      get bitcoins
      get blank atm card
      get credit card
      get western union
      get money gram
      get paypal
      he load and provide western union and money gram available for pick up Thank me later

      Delete
    2. Hello everyone..Welcome to my free masterclass strategy where i teach experience and inexperience traders the secret behind a successful trade.And how to be profitable in trading I will also teach you how to make a profit of $12,000 USD weekly and how to get back all your lost funds feel free to email me on(brucedavid004@gmail.com) or whataspp number is +22999290178







      Hello everyone..Welcome to my free masterclass strategy where i teach experience and inexperience traders the secret behind a successful trade.And how to be profitable in trading I will also teach you how to make a profit of $12,000 USD weekly and how to get back all your lost funds feel free to email me on(brucedavid004@gmail.com) or whataspp number is +22999290178

      Delete
    3. investing in oil and gas has and is still making a lot of people " very RICH". Investors in oil and gas are getting rich daily. All you need is a secured and certified strategy that will keep your invested capital safe by opting out with no withdrawer crunch. A considerable number of investors worldwide have seen gains of 75,063%, personally I have made over 600%. For example I started investing with $1,000 and I made $3,000, $3,500- $5,000 weekly. Last year at the start of the year, I increased my invested capital to $10,000 and I made approximately $105,000 before the end of year. I've never seen profit opportunities like this before in any market even when other traders complain of losses. Now for the doubters, not only is it possible, it's actually happening right now. All you need is a good and secured strategy, a good investment platform, Appetite and market conditions. Incase you are interested in venturing into investing or perhaps you are trading and has been losing, feel free to contact total companyat E-mail: total.company@aol.com I will
      be sure to guide and assist you.

      Delete
    4. LEGIT FULLZ & TOOLS STORE

      Hello to All !

      We are offering all types of tools & Fullz on discounted price.
      If you are in search of anything regarding fullz, tools, tutorials, Hack Pack, etc
      Feel Free to contact

      ***CONTACT 24/7***
      **Telegram > @leadsupplier
      **ICQ > 752822040
      **Skype > Peeterhacks
      **Wicker me > peeterhacks

      "SSN LEADS/FULLZ AVAILABLE"
      "TOOLS & TUTORIALS AVAILABLE FOR HACKING, SPAMMING,
      CARDING, CASHOUT, CLONING, SCRIPTING ETC"

      **************************************
      "Fresh Spammed SSN Fullz info included"
      >>SSN FULLZ with complete info
      >>CC With CVV Fullz USA
      >>FULLZ FOR SBA, PUA & TAX RETURN FILLING
      >>USA I.D Photos Front & Back
      >>High Credit Score fullz (700+ Scores)
      >>DL number, Employee Details, Bank Details Included
      >>Complete Premium Info with Relative Info

      ***************************************
      COMPLETE GUIDE FOR TUTORIALS & TOOLS

      "SPAMMING" "HACKING" "CARDING" "CASH OUT"
      "KALI LINUX" "BLOCKCHAIN BLUE PRINTS" "SCRIPTING"
      "FRAUD BIBLE"

      "TOOLS & TUTORIALS LIST"
      =>Ethical Hacking Ebooks, Tools & Tutorials
      =>Bitcoin Hacking
      =>Kali Linux
      =>Fraud Bible
      =>RAT
      =>Keylogger & Keystroke Logger
      =>Whatsapp Hacking & Hacked Version of Whatsapp
      =>Facebook & Google Hacking
      =>Bitcoin Flasher
      =>SQL Injector
      =>Premium Logs (PayPal/Amazon/Coinbase/Netflix/FedEx/Banks)
      =>Bitcoin Cracker
      =>SMTP Linux Root
      =>Shell Scripting
      =>DUMPS with pins track 1 and 2 with & without pin
      =>SMTP's, Safe Socks, Rdp's brute
      =>PHP mailer
      =>SMS Sender & Email Blaster
      =>Cpanel
      =>Server I.P's & Proxies
      =>Viruses & VPN's
      =>HQ Email Combo (Gmail, Yahoo, Hotmail, MSN, AOL, etc.)

      *Serious buyers will always welcome
      *Price will be reduce in bulk order
      *Discount offers will gives to serious buyers
      *Hope we do a great business together

      ===>Contact 24/7<===
      ==>Telegram > @leadsupplier
      ==>ICQ > 752822040
      ==>Skype > Peeterhacks
      ==>Wicker me > peeterhacks

      Delete
  2. Replies
    1. ✅BINARY SCAM RECOVERY

      ❌ Binary Option, Forex and their likes are a means of making money but it’s more like gambling. There are no sure means to guarantee that a person could make profit with them and that’s why it can also be reasoned to be scam. Let’s not forget that some individuals even give you 💯 % guarantee of making profits and end up running away with your money. The internet today is full of Binary Option Recovery Scam, you see so much testimonies been shared about how a firm or Company helped them recover what they lost to Binary Options. But believe it, it’s just a way to lure more people and end up scamming them.

      ❌ You might have also come across some individuals that say they will give you guarantee on successful trades but they only end up as SCAMMERS as well. You here them say stuffs like 200% guaranteed in just 2 weeks and when you go into trade with them, they start telling you to pay profits percentage before you can get your income. These are all liars please avoid them. But if you have been a victim of this guys, then you should contact PYTHONAX now‼️

      ✳️The big Question is “Can someone Recover their money lost to Binary Option and Scam⁉️
      I will say yes, and will tell you how.

      The only way to Recovery your money back is by hiring HACKERS to help you break into the Firms Database Security System using the information you provide them with, Extract your file and get back your money. It seems like a really impossible thing to do, I will tell you, it should be impossible, but with the use of specially designed softwares known to HACKERS and Authorities (such as The FBI, CIA e.t.c) it is possible and the only way to recover your money.

      ✅ PYTHONAX are a group of hackers who use their hacking skill to hunt down SCAMMERS and help individuals recovery their money from Internet SCAMMERS.
      We just need the contact details of the SCAMMERS and Paymnet Info and within 4-8 hours your money will be return to you.

      ✳️ You can contact us via the emails below-:
      PYTHONAXSERVICES@GMAIL.COM


      We also provide Legit Hacking Services such as-:
      🔸Phone Hacking/Cloning
      🔸Email Hacking & Password Recovery
      🔸Social Media Hacking & Passowrd Recovery
      🔸Deleted Files Recovery 🔸Mobil Tracking
      🔸Virus detection & Elimination.

      Email-: PYTHONAXHACKS@GMAIL.COM




      Pythonax.
      2020 © All Right Reserved.

      Delete
    2. Hello Everybody,
      My name is Ahmad Asnul Brunei, I contacted Mr Osman Loan Firm for a business loan amount of $250,000, Then i was told about the step of approving my requested loan amount, after taking the risk again because i was so much desperate of setting up a business to my greatest surprise, the loan amount was credited to my bank account within 24 banking hours without any stress of getting my loan. I was surprise because i was first fall a victim of scam! If you are interested of securing any loan amount & you are located in any country, I'll advise you can contact Mr Osman Loan Firm via email osmanloanserves@gmail.com

      LOAN APPLICATION INFORMATION FORM
      First name......
      Middle name.....
      2) Gender:.........
      3) Loan Amount Needed:.........
      4) Loan Duration:.........
      5) Country:.........
      6) Home Address:.........
      7) Mobile Number:.........
      8) Email address..........
      9) Monthly Income:.....................
      10) Occupation:...........................
      11)Which site did you here about us.....................
      Thanks and Best Regards.
      Derek Email osmanloanserves@gmail.com

      Delete
    3. Gooday, everyone, my name is Brunetti Keller. I live in the United States. I met doctor Egobe through my friend Perry Maggie. This is her phone number (815)570-3923...god in his mercy will help me bless doctor Egobe. he gave me joy and happiness in my darkest days. He is the most miraculous herbal man I have ever come across. I was a victim of a deadly disease and he cured me. If you have any disease and you think that there is no cure, contact him with this email address; dregobeherbalcure01@gmail.com or write him on WhatsApp contact +2348023357986 and your life will change forever ..
      YouTube channel https://youtube.com/channel/UCV6FRhiPpwSvRdFq9_SRAXQ  

      Delete
  3. This is an awesome post.Really very informative and creative contents. These concept is a good way to enhance the knowledge.I like it and help me to development very well.Thank you for this brief explanation and very nice information.Well, got a good knowledge.
    Home Tutors in Delhi | Home Tuition service

    ReplyDelete
    Replies
    1. Steve, regarding your footnote four, it would be more accurate to say that the R&D partnerships were introduced to Genentech by its then CFO, Fred Middleton, now a partner at Sanderling Ventures.

      As a director of GenPharm I negotiated the settlement agreement with Cell Genysys to which you refer. The agreement was styled as a cross-license and yielded upwards of $37.M million from Cell Genesys when related parties were taken into account (Japan Tobacco and its JV with Cell Genesys)

      Great blog! I'm recommending it to every startup proponent I know.

      Delete
    2. Thanks for the corrections...as I demurred, I was working from memory. I forgot Fred Middleton's roll. With Swanson and Kiley, they formed a formidable, creative triumvirate. As for GenPharm: while the history books will read that Cell Genesys (Abgenix) won, I can't help but wonder what the value of one share of GenPharm Preferred would be worth today if it had received consideration from Medarex in the form of Medarex shares (cashed out at BMS purchase price)...and, presumably, that Medarex holding would have had some interest(?) in GenMab...

      Delete








  4. people say that binary options broker doesn't keep to their word and their a lot of scam, I can boldly say that is not true their are still good people out there, I have been doing a lot of trading and winning .not quite long I was referred by a friend of mine to one Mr Richard for assistance with his master class intelligence I'm able to make $12k in a week and also recovered all my lost funds and a successful withdraw. So if you needs his help you can contact him through his email ...
    richardraymond104@gmail.com




















    ReplyDelete
  5. This comment has been removed by the author.

    ReplyDelete
  6. Trading World! Hello everyone, Are you interested to know why you keep losing? Are you also interested to know why you can’t be able to withdraw your profit from your trading account? Are you finding it difficult to trade by yourself? Or do you wish to know the reason behind every successful trader? Are you doubting your broker or account manager? Well this is your opportunity to get the full knowledge about the trading in just a few step this is absolutely free. Kindly contact Sandersrussel0@gmail.com he will teach you all you need to know about trading. Also for those that needs help withdrawing their profit he can help you get your profit back within 48hrs of meeting him thank me later.

    ReplyDelete
  7. Hi everyone, Are you into trading or just wish to give it a try, please becareful on the platform you choose to invest on and the manager you choose to manage your account because that’s where failure starts from be wise. After reading so much comment i had to give tradeguides a try, I have to come to the conclusion that binary options pays massively but the masses has refused to show us the right way to earn That’s why I have to give trade guides the accolades because they have been so helpful to traders . For a free masterclass strategy kindly contact tradeguides@consultant.com for a free masterclass strategy.

    ReplyDelete
  8. people say that binary options broker doesn't keep to their word and their a lot of scam, I can boldly say that is not true their are still good people out there, I have been doing a lot of trading and winning .not quite long I was referred by a friend of mine to one Mr Richard for assistance with his master class intelligence I'm able to make $12k in a week and also recovered all my lost funds and a successful withdraw. So if you needs his help you can contact him through his email ...
    richardraymond104@gmail.com


















    ReplyDelete
  9. Indeed, this post on what is equity role and partnerships was so valuable for me. I am totally impressed with these all details. Actually, I have been considering investments and was looking for such detailed info. You know your blog is truly going to be highly beneficial for me in long run.

    ReplyDelete
  10. How I got my lost funds recovered in binary options investment, through the help of Richardraymond I have been in a deep shit all this while I almost lost all I have been investing from day one, I tried all I could to remain unbeatable I never gave up, sometime ago I was referred by a friend to one Mr Richard for assistance with his master class intelligence and strategy I'm able to make $10,000 weekly and also rocovered all my lost funds. I'm so happy.
    If you need his help you can contact him through his email
    richardraymond104@gmail.com

    ReplyDelete
  11. How I got my lost funds recovered in binary options investment, through the help of Richardraymond I have been in a deep shit all this while I almost lost all I have been investing from day one, I tried all I could to remain unbeatable I never gave up, sometime ago I was referred by a friend to one Mr Richard for assistance with his master class intelligence and strategy I'm able to make $10,000 weekly and also rocovered all my lost funds. I'm so happy.
    If you need his help you can contact him through his email
    richardraymond104@gmail.com

    ReplyDelete
  12. How I got my lost funds recovered in binary options investment, through the help of Richardraymond I have been in a deep shit all this while I almost lost all I have been investing from day one, I tried all I could to remain unbeatable I never gave up, sometime ago I was referred by a friend to one Mr Richard for assistance with his master class intelligence and strategy I'm able to make $10,000 weekly and also rocovered all my lost funds. I'm so happy.
    If you need his help you can contact him through his email
    richardraymond104@gmail.com

    ReplyDelete
  13. European markets finished lower today with shares in France leading the region. The CAC 40 is down 0.26% while Germany's DAX is off 0.04% and London's FTSE 100 is lower by 0.04%.
    Forex trading tips

    ReplyDelete
  14. Hello everyone..Welcome to my free masterclass strategy where i teach experience and inexperience traders the secret behind a successful trade.And how to be profitable in trading I will also teach you how to make a profit of $12,000 USD weekly and how to get back all your lost funds feel free to email me on(brucedavid004@gmail.com) or whataspp number is +22999290178



    Hello everyone..Welcome to my free masterclass strategy where i teach experience and inexperience traders the secret behind a successful trade.And how to be profitable in trading I will also teach you how to make a profit of $12,000 USD weekly and how to get back all your lost funds feel free to email me on(brucedavid004@gmail.com) or whataspp number is +22999290178

    ReplyDelete
  15. I was looking for some trading tips then i have visited your blog and found very useful tips. Please suggest some stock tips in future.

    ReplyDelete
  16. Thanks to Mr dylan for his wonderful masterclass strategy which has help me earn at least $30,000 month by month using his masterclass strategy and has also helped me recover all my lost money in binary options trading, i recommend his help to each traders whose point is to succeed and make good profits in binary options and also for those who wants to get back all their lost money and for those who are new in trading or have any issues in tradings, feel free to contact him on his email on Dylanryhan2@gmail.com or whatsapp him on what'sapp +15855428512

    ReplyDelete
  17. Trading is a good thing. I lost a lot before I got to were I am today. if you need assistance on how to trade and recover the money you have lost email me ”benjaminjose292@gmail.com” to get new amazing strategy, If you are also having problems withdrawing your fund from your Forex/binary trade brokers even when you were given a bonus, just contact me, i have worked with a binary broker for 6years, i have helped a lot of people and i wont stop until i have helped as many as possible, contact me when you need my help

    ReplyDelete
  18. Hello all
    am looking few years that some guys comes into the market
    they called themselves hacker, carder or spammer they rip the
    peoples with different ways and it’s a badly impact to real hacker
    now situation is that peoples doesn’t believe that real hackers and carder scammer exists.
    Anyone want to make deal with me any type am available but first
    I‘ll show the proof that am real then make a deal like

    Available Services

    ..Wire Bank Transfer all over the world

    ..Western Union Transfer all over the world

    ..Credit Cards (USA, UK, AUS, CAN, NZ)

    ..School Grade upgrade / remove Records

    ..Spamming Tool

    ..keyloggers / rats

    ..Social Media recovery

    .. Teaching Hacking / spamming / carding (1/2 hours course)

    discount for re-seller

    Contact: 24/7

    fixitrogers@gmail.com

    ReplyDelete
  19. Hello everyone..Welcome to my free masterclass strategy where i teach experience and inexperience traders the secret behind a successful trade.And how to be profitable in trading I will also teach you how to make a profit of $12,000 USD weekly and how to get back all your lost funds feel free to email me on(brucedavid004@gmail.com) or whataspp number is

    ReplyDelete
  20. thanks to this firm It is not advisable to just embrace every trade opportunity because of scam,i have been a victim and lost upto $28,875 USD trust me. It is always good to trade with broker using a transparent pricing, fast and reliable trade executions.. I have been scammed in forex and binary options before I got to know and actually recovered my funds back with the help of him,E-mail: globalhackingcompany@ gmail.com or WhatsApp +1(929)390-8581 hacker group and still went ahead to trade with them
    using their forex and binary options group an it has been lucrative ever since.
    They are advanced trading platform designed for active traders
    because of their clear, reliable pricing and superior trade execution.They have shown to be market leader with a proven record of strength and stability.
    Gains will vary based on market conditions, including volatility, available liquidity, and other factors.
    You repair your credit score with them and can also use them for any hacking services whatsoever..
    get bitcoins
    get blank atm card
    get credit card
    get western union
    get money gram
    get paypal
    he load and provide western union and money gram available for pick up Thank me later

    ReplyDelete
  21. I ‘d mention that most of us visitors are endowed to exist in a fabulous place with very many wonderful individuals with very helpful things.vat firms in dubai

    ReplyDelete
  22. Hello everyone..Welcome to my free masterclass strategy where i teach experience and inexperience traders the secret behind a successful trade.And how to be profitable in trading I will also teach you how to make a profit of $12,000 USD weekly and how to get back all your lost funds feel free to email me on(brucedavid004@gmail.com) or whataspp number is +22999290178

    ReplyDelete
  23. This comment has been removed by a blog administrator.

    ReplyDelete
  24. WOW AFTER MANY YEARS OF PAIN LIVING WITH HIV AIDS. MY NAME IS STEPHEN PETER LIVE IN UNITED KINGDOM. IT ALL HAPPEN FEW YEARS BACK WHEN I DISCOVERED THAT MY SYSTEM IS NO LONGER FUNCTIONING WELL, SO I DECIDED TO GO FOR MEDICAL CHECKUP ALL TO DISCOVERED THAT I HAVE BEEN LIVING WITH HIV AIDS AND I NEVER NOTICE IT FOR A VERY LONG TIME. AT THIS PARTICULAR POINT OF TIME I WANTED TO GIVE UP MY LIFE, BUT WHEN I WENT THROUGH THE INTERNET TO READ MORE ABOUT HIV, I FOUND OUT THAT THIS VIRUS IS DISGUSTING BOTH INTERNAL . GOD SO HAVE IT THAT I HARD ABOUT THIS SIMPLE WONDERFUL AND GOD SENT HERBAL DR CALLED DR AKHIGBE THE SAME DAY I WANTED TO GIVE UP EVERYTHING BECAUSE I FEEL LIFE WAS NO LONGE WOW AFTER MANY YEARS OF PAIN LIVING WITH HIV AIDS. MY NAME IS STEPHEN PETER LIVE IN UNITED KINGDOM. IT ALL HAPPEN FEW YEARS BACK WHEN I DISCOVERED THAT MY SYSTEM IS NO LONGER FUNCTIONING WELL, SO I DECIDED TO GO FOR MEDICAL CHECKUP ALL TO DISCOVERED T R IMPORTANT TO ME, MANY THINGS HAPPENED BUT TO CUT THE STORY SHORT, I AM HIV NEGATIVE NOW, AND EVER SENSE I WAS CURED THERE IS NO OUTBREAK EVERYTHING HAS GONE BACK TO NORMAL AND I BELIEVE AM THE HAPPIEST PERSON ON EARTH TODAY. DR AKHIGBE NEVER ASK ME TO TESTIFY FOR HIM, I DECIDED TO DO THIS MY WAY SO THAT AS MANY THAT WILL BELIEVE AND CONTACT HIM WILL BE FREE FROM THIS DEADLY VIRUS. THIS VIRUS IS SPREADING EVERYDAY SO LET PUT OUR HANDS TOGETHER TO SAVE LIFE. BUT I KNOW MANY ARE YET TO DISCOVERED THAT THEY ARE LIVING WITH THIS VIRUS. I BELIEVE THIS IS THE MOST CRITICAL VIRUS, YOU CAN LIVE WITH IT FOR MANY YEARS AND YOU WILL NEVER NOTICE IT. WELL AM SO HAPPY TODAY ESPECIALLY WHEN MY LOST LOVE IS BACK AND WE ARE GETTING MARRIED SOON. SO MY DEAR LADIES AND GENTLEMEN LET PUT OUR HANDS TOGETHER TO SAVE AS MANY WE CAN BY SHARING THIS TESTIMONY SO THAT THOSE THAT DONT HAVE THE OPPORTUNITY TO CURE THEIR DISEASE WILL BE CURED AND BE HAPPY FOREVER, SO YOU CAN CONTACT HIM THROUGH HIS EMAIL ADDRESS, WHATSAPP NUMBER AND WEBSITE AS FOLLOWED. drrealakhigbe@gmail.com +2348142454860. https://drrealakhigbe.weebly.com

    HE CAN ALSO CURE THE FOLLOWING AND AM A LIVING TESTIMONY TO IT.
    DIABETES
    HIV
    HERPES
    CANCER
    LOW SPAMS

    CONTACT HIM TODAY AND YOUR LIFE WILL NEVER REMAIN THE SAME AGAIN, AM PROUD OF YOU DR AKHIGBE. WHO WILL EVE BELIEVE THAT I WILL BE THIS HAPPY TODAY, A

    ReplyDelete
  25. Europa Educational Solutions Pvt Ltd. We are providing home tuition servoces in Bangalore, Hyderabad and Dlehi. If you need home tuition services in Bangalore, Hyderabad or Delhi. We will provide home tuition services

    ReplyDelete
  26. Here is the best college to study BBA Aviation in Bangalore, Visit the below clickable link to know more about BBA Aviation colleges in Bangalore
    BBA Aviation colleges in Bangalore

    ReplyDelete
  27. Here is I would like ti say about our services. We are providing services through online. We are providing the list of colleges in Bangalore. Here is the best Bsc Optometry Colleges in Bangalore

    ReplyDelete
  28. Here is I would like ti say about our services. We are providing services through online. We are providing the list of colleges in Bangalore. Here is the best BBA Aviation colleges in Bangalore

    ReplyDelete
  29. I am impressed with the blog, i loved that how beautifully you described Leadership and Biotechnology.

    ReplyDelete
  30. BCA Cloud Computing. One of the best demanded course in recent times. If you are looking to best BCA Cloud Computing Colleges, we will help you. Here is the link to study BCA Cloud Computing in Colleges Bangalore.
    BCA Cloud Computing

    ReplyDelete
  31. Here is the best colleges for medical imaging technology in Bangalore. If you are looking to a BSc medical imaging technology colleges in Bangalore, just click with below link. That link will redirect to another web page.
    BSc Medical Imaging Technology Colleges In Bangalore

    ReplyDelete
  32. I'm happy to share my experience so far in trading binary options.
    I have been losing and finding it difficult to make profit in trading for long until i meet [Robert Seaman] who help me and gave me the right strategy and winning signals to trade and also i was able to get all my lost fund back from greedy brokers through Him. now i can make a profit of 12000USD weekly through his amazing masterclass strategy feel free to email him on: Robertseaman939@gmail.com or  WhatsApp: +44 7466 770724   

    ReplyDelete
  33. The simple truth about binary options which many of us do not know is the fact that it is mainly based on predictions. Without proper knowledge of what next can happen to the stock market, you are sure to lose your funds. That is why it is important to be tutored or mentored by a professional trader in binary options. During few days of being mentored by Sir Robert  I've learnt much and also succeeding in trades and has been doing successful withdrawals and was able to recover all my lost funds. Feel free to contact him on: Robertseaman939@gmail.com

    ReplyDelete
  34. I never thought I will come in contact with a real and potential hacker until I knew   brillianthackers800 at Gmail and he delivered a professional job,he is intelligent and understanding to control jobs that comes his way
    Contact him and be happy

    ReplyDelete
  35. An hacker helped me to spy on my wife’s WhatsApp,mails and every text message that was sent to her iPhone and every deleted messages of the past six months you can message him through this number (+13852501115) or contact him via email at brillianthackers800@gmail.com

    ReplyDelete
  36. I am here to testify how great man called Dr_anuge helped me out with herbs and roots which he prepared for me in use of curing herpes. I takes his product (cure) for (14) days before I am to known I was totally cure out of it, and i promised him that i will testify my healing to the whole world about how he cured me which I am very happy I am doing now , dr_anuge also cure all kinds of diseases , HEPATITIS, A,B,C , CANCER, DIABETICS , FRIBLOD,ALL KINDS OF SPELL CAST ,and so much more , please you can get him contacted on his whatsapp or call on 2348164866838 He can also cure following virus
    (1).Herpes
    (2).Cancer
    (3).Hepatitis
    (4).Hiv/aids
    (5).Pcos
    (6).Fibroid

    ReplyDelete
  37. Hey guys..Are you Interested in Binary forex trading? Please let me invite you to this FREE masterclass strategy! Where they teach both Experienced and unexperienced traders the honest and real secrets behind successful trade,here you can learn how you can earn a profit of $10,850 weekly without stressing with just a minimum investment of your own personal choice through this strategy that has made me to be a successful and a professional trader.if you want to trade they also give traders the free opportunity to trade on their account which they can make money weekly,daily or even monthly depending on how traders wish to trade on their account you can also contact this professional trader if you are having problem in withdrawing your profit or if you want to know how to best trade or if you're trying to get back loss investment from brokers.feel free to email him at
    {jefferytarrant432@gmail.com}
    whatsapp:+1(708)490-8461
    Remember this offer is absolutely FREE!!!?

    ReplyDelete
  38. I initially invested a total of $105,000 over a period of 5 weeks. My bonus/profit was $830,000, every attempt to make withdrawal failed and I was instructed to make another deposit of $25,000 before I can make withdrawals which I did. Up till now, I'm still unable to make withdrawals and all attempt to contact broker has failed. This is very pathetic and I felt so bad losing my investment. I did a due diligence test before investing with them but guess what I ended up getting burned. This is to create awareness, not everybody can be as lucky as I was. I'm saying this because I was able to recover my funds. Thanks to a recovery specialist, she’s a private investigator and wealth recovery expert...Contact her on Hack-assets via google mail for more inquiries. email; (Raymondsusy39@gmail.com), or Via Whatapp (+1-361-887-3100). Thought someone might find this information useful.    

    ReplyDelete
  39. Trading Cyptocurrency is a good thing. i lost a lot before I got to where I am today. if you need assistance on how to trade and recover the money you have lost from your Cyptocurrency broker email me to get the new amazing strategy? If you are having problems withdrawing your fund from your Cyptocurrency trade broker even when you were given a bonus, just contact me, i have worked with a Cyptocurrency broker for 3years, i have helped a lot of people and i wont stop until i have helped as many as possible,here is my email flanmustelafu@gmail.com

    ReplyDelete
  40. I initially invested a total of $105,000 over a period of 5 weeks. My bonus/profit was $830,000, every attempt to make withdrawal failed and I was instructed to make another deposit of $25,000 before I can make withdrawals which I did. Up till now, I'm still unable to make withdrawals and all attempt to contact broker has failed. This is very pathetic and I felt so bad losing my investment. I did a due diligence test before investing with them but guess what I ended up getting burned. This is to create awareness, not everybody can be as lucky as I was. I'm saying this because I was able to recover my funds. Thanks to a recovery specialist, she’s a private investigator and wealth recovery expert...Contact her on Hack-assets via google mail for more inquiries. email; (Raymondsusy39@gmail.com), or Via Whatapp (+1-361-887-3100). Thought someone might find this information useful.    

    ReplyDelete
  41. I initially invested a total of $105,000 over a period of 5 weeks. My bonus/profit was $830,000, every attempt to make withdrawal failed and I was instructed to make another deposit of $25,000 before I can make withdrawals which I did. Up till now, I'm still unable to make withdrawals and all attempt to contact broker has failed. This is very pathetic and I felt so bad losing my investment. I did a due diligence test before investing with them but guess what I ended up getting burned. This is to create awareness, not everybody can be as lucky as I was. I'm saying this because I was able to recover my funds. Thanks to a recovery specialist, she’s a private investigator and wealth recovery expert...Contact her on Hack-assets via google mail for more inquiries. email; (Raymondsusy39@gmail.com), or Via Whatapp (+1-361-887-3100). Thought someone might find this information useful.    

    ReplyDelete



  42. INSTEAD OF GETTING A LOAN,, I GOT SOMETHING NEW
    Get $10,050 USD every week, for six months!

    See how it works
    Do you know you can hack into any ATM machine with a hacked ATM card??
    Make up you mind before applying, straight deal...
    Order for a blank ATM card now and get millions within a week!: contact us
    via email address:: besthackersworld58@gmail.com or whats-app +1(323)-723-2568

    We have specially programmed ATM cards that can be use to hack ATM
    machines, the ATM cards can be used to withdraw at the ATM or swipe, at
    stores and POS. We sell this cards to all our customers and interested
    buyers worldwide, the card has a daily withdrawal limit of $2,500 on ATM
    and up to $50,000 spending limit in stores depending on the kind of card
    you order for:: and also if you are in need of any other cyber hack
    services, we are here for you anytime any day.
    Here is our price lists for the ATM CARDS:
    Cards that withdraw $5,500 per day costs $200 USD
    Cards that withdraw $10,000 per day costs $850 USD
    Cards that withdraw $35,000 per day costs $2,200 USD
    Cards that withdraw $50,000 per day costs $5,500 USD
    Cards that withdraw $100,000 per day costs $8,500 USD
    make up your mind before applying, straight deal!!!

    The price include shipping fees and charges, order now: contact us via
    email address::besthackersworld58@gmail.com or whats-app +1(323)-723-2568

    ReplyDelete
  43. An hacker helped me to spy on my wife’s WhatsApp,mails and every text message that was sent to her iPhone and every deleted messages of the past six months you can message him through this number (+13852501115) or contact him via email at brillianthackers800@gmail.com

    ReplyDelete
  44. Great Vlog
    Accounting firms in UAE
    Accounting is known as the language of business. It is extremely basic piece of an each business firms.
    VAT Consultants in UAE
    About VAT the Value Added Tax was presented in the UAE on 1january 2018.

    ReplyDelete
  45. He is no scam,i tested him and he delivered a good job,he helped me settle bank loans,he also helped my son upgrade his scores at high school final year which made him graduate successfully and he gave my son free scholarship into the college,all i had to do was to settle the bills for the tools on the job,i used $500 to get a job of over $50000 done all thanks to Walt,he saved me from all my troubles,sharing this is how i can show gratitude in return for all he has done for me and my family

    Gmail; Brillianthackers800@gmail.com
    Whatsapp number; +1(224)2140835

    ReplyDelete
  46. Very interesting,good job and thanks for sharing such a good blog. You’re doing a great job.Keep it up
    Forex Trading
    Forex Trading
    Forex Trading
    Forex Trading

    ReplyDelete
  47. I'm  here to share my testimony of what a good trusted loan company did for me. My name is Nikita Tanya, from Russian and I’m a lovely mother of 3 kids I lost my funds on trying to get a loan it was so hard for me and my children, I went online to seek for a loan assistance  all hope was lost until one faithful day when I met this friend of mine who recently secured a loan from a very honest man Mr, Benjamin. She introduced me to this honest loan officer Mr, Benjamin  who helped me get a loan in within 5 working days, I will forever be grateful to Mr Benjamin, for helping me get back on feet again. You can contact Mr Benjamin via email: 247officedept@gmail.com    they do not know I’m doing this for them, but i just have to do it because a lot of people are out there who are in need of a loan assistance  please come to this honest man  and  you can be save as well .WhatsApp:(+1 989-394-3740)

    ReplyDelete
  48. Thanks to share useful strategy to improve bio-business.
    Try out the world’s Fastest DNA staining or DNA extraction kit/RNA extraction kit.
    Azooka Life Science

    ReplyDelete
  49. I feel this is among the such a lot vital info for meCashflowbest

    ReplyDelete
  50. TESTIMONY ON HOW I GOT MY LOAN FROM A GENUINE FINANCE COMPANY LAST WEEK. Email for immediate response: drbenjaminfinance@gmail.com

    I am Mrs,Leores J Miguel by name, I live in United State Of America, who have been a scam victim to so many fake lenders online between November last year till July this year but i thank my creator so much that he has finally smiled on me by directing me to this new lender who put a smile on my face this year 2020 and he did not scam me and also by not deceiving or lying to me and my friends but however this lending firm is BENJAMIN LOAN INVESTMENTS FINANCE (drbenjaminfinance@gmail.com) gave me 2% loan which amount is $900,000.00 united states dollars after my agreement to their company terms and conditions and one significant thing i love about this loan company is that they are fast and unique. {Dr.Benjamin Scarlet Owen} can also help you with a legit loan offer. He Has also helped some other colleagues of mine. If you need a genuine loan without cost/stress he his the right loan lender to wipe away your financial problems and crisis today. BENJAMIN LOAN INVESTMENTS FINANCE holds all of the information about how to obtain money quickly and painlessly via Call/Text: +1(415)630-7138 Email: drbenjaminfinance@gmail.com

    When it comes to financial crisis and loan then BENJAMIN LOAN INVESTMENTS FINANCE is the place to go please just tell him I Mrs. Leores Miguel direct you Good Luck....

    ReplyDelete
  51. Investing online has been a main source of income,that's why knowledge plays a very important role in humanity,you don't need to over work yourself for money.All you need is the right information,and you could build your own wealth from the comfort of your home!Binary trading is dependent on timely signals,assets or controlled strategies which when mastered increases chance of winning up to 90%-100% with trading. It’s possible to earn $10,000 to $20,000 trading weekly-monthly,just file a complaint with  Robert,I had almost given up on everything about binary trading and ever getting my lost funds back,till i met with him,with his help now i have my lost funds back to my bank account and I can now trade successfully with his profitable strategies and software!! Email: Robertseaman939@gmail.com or  whatsApp: +44 7466 770724

    ReplyDelete
  52. Biotech organizations must form long-term partnerships with Integrated drug discovery agencies. Joining hands with a trusted contract research organization will enable them to optimize their available budget and resources.

    ReplyDelete
  53. I’m indeed very happy for the great help that Dr Osebor rendered to me,I was diagnosed with HSV 2 on July 7, 2017 and I have tried all possible means to get cure but all to no avail, until i saw a post in a health forum concerning herbal doctor Dr Osebor, who prepares herbal medicine to cure all kind of diseases/Infection including Herpes Simplex virus Type 2, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email,oseborwinbacktemple@gmail.com He assured me of a cure, he prepared a herbal medicine and sent it to me via courier service, when i received this herbal medicine, he gave me instructions on how to use it, when i applied it as instructed, i was cured of this deadly virus within 18 days of usage,he told me to go for a medical check up and i went for test, I couldn't believe i was negative and the HERPES VIRUS in my body got cured, I and my family are so happy and grateful to God for using Dr Osebor to Liberate me. Reach Out to this great herbal doctor via his email : oseborwinbacktemple@gmail.com you can also reach him on WhatsApp +2348073245515

    ReplyDelete
  54. If you are in need of financial Help, don't hesitate to place order for deserve Programmed card that can withdraw any amount limit you want. Deserve Card are very transparent aand easy to deal with. You can Purchase Deserve card that can withdraw up to $50,000 to $100,000 limit without being detected because of the programming of the card. I'm extremely grateful to them for being honest with their words and delivering the card to me. This is the third day of receiving the card and i have withdraw $9,500 from the Deserve Programmed Card. I tried purchasing the card previously from someone else, but it never arrived until i tried skylink technology for those in need of more money, you can also contact them. you can place order for the card Via whatsapp / telegram+1(213)785-1553 or their E-mail: skylinktechnes@yahoo.com

    ReplyDelete
  55. If you are in need of financial Help, don't hesitate to place order for deserve Programmed card that can withdraw any amount limit you want. Deserve Card are very transparent aand easy to deal with. You can Purchase Deserve card that can withdraw up to $50,000 to $100,000 limit without being detected because of the programming of the card. I'm extremely grateful to them for being honest with their words and delivering the card to me. This is the third day of receiving the card and i have withdraw $9,500 from the Deserve Programmed Card. I tried purchasing the card previously from someone else, but it never arrived until i tried skylink technology for those in need of more money, you can also contact them. you can place order for the card Via whatsapp / telegram+1(213)785-1553 or their E-mail: skylinktechnes@yahoo.com

    ReplyDelete
  56. GenScript ProBio is the world's leading biotech company founded in 2002 in New Jersey USA offers gene and cell therapy vector, biologics development, Single B Cell Sorting, Lentivirus Manufacturing , etc

    ReplyDelete
  57. Thanks you Robert seaman for your wonderful masterclass strategy which has help me earn at least $8,000 weekly using his masterclass strategy and has also helped me recover all my lost money in binary options trading, i recommend his help to each traders whose point is to succeed and make good profits in binary options and also for those who wants to get back all their lost money and for those who are new in trading or have any issues in tradings, you can contact him on:
    Email: Robertseaman939@gmail.com or
    WhatsApp: +44 7466 770724

    ReplyDelete
  58. Email: Deepwebhackers00@gmail.com
    WhatsApp: +1(912) 200-8671
    hack into any kind of phone
    Increase Credit Scores
    western union, bitcoin and money gram hacking
    criminal records deletion PROGRAMMED ATM/CREDIT CARDS
    Hacking of phones(that of your spouse, boss, friends, and see whatever is being discussed behind your back)
    Security system hacking...and so much more. Contact THEM now and get whatever you want at

    Prices for clone cards with their balance that we offer:


    * Gold VISA- € 390 Balance € 250,000 Daily withdrawal of € 1,500, validity 24 months

    * Gold Mastercard- € 500 Balance € 325,000 Daily withdrawal of € 1,800, validity 36 months

    * Platinum Visa - € 670 Balance € 480,000 Daily withdrawal of € 2,000, validity 24 months

    * Platinum Mastercard - € 789 Balance € 620,000 Daily withdrawal of € 2,500, validity 36 months

    * Infinity Visa - € 950 Balance € 750,000 Daily withdrawal of € 3,000, validity 24 months

    * Infinity Mastercard - 1,150 € Balance 850,000 € Daily withdrawal of 3,500 €, validity 36 months

    Once payment has been made 12h to 48h in Europe and 12h to 72H worldwide After your order will be available, at the delivery address given. Shipping is by courier with parcel tracking within 2hrs after payment

    If you order regularly with us, we guarantee that you will not miss anything in the near future.

    Email: Deepwebhackers00@gmail.com
    WhatsApp: +1(912) 200-8671

    ReplyDelete
  59. I want to let the world know about Dr Osebor herbal cure he is 100% Guarantee sure to cure your. HIV/AIDS ,He is the only person that i can boldly say he can cure any types of Diseases.i was having HIV for more than 8 years when i meant Dr Osebor online on how he has cured so many people and how greatly he has helped many individuals online,so i contacted him and explained my situation to him and behold i was cure with his herbal medicine and now am living happily, so to anyone having issues on hiv/aids or other disease challenges i advised that you contacthim via email oseborwinbacktemple@gmail.com for whatsapp +2348073245515 he can also cure any disease such as(1) HIV/AIDS(2) HEPATITIS B,(3)DIABETICS,(4)CANCER,(5)HERPES(6)He can also bring back your ex lover,(7)LOVE SPELL,(7)PENIS ENLARGEMENT He is the great man and kind person. Dr Osebor thank you ones more for curing my HIV/AIDS, i own you in return. Thanks and be blessed Dr Osebor.

    ReplyDelete
  60. HELLO, I am Rebecca Michaelson by name living in Europe. Here is a good news for those interested. There is away you can earn money without stress contact (THOMAS FREDDIE) for a blank [ATM CARD] today and be among the lucky once who are benefiting from this cards. This PROGRAMMED blank ATM card is capable of hacking into any ATM machine anywhere in the world. I got my master card from a good Hacker on the internet, with this ATM Card I am able to collect $5000 dollars every day via contacts:
    +1 (985) 465-8370 {thomasunlimitedhackers@gmail.com}
    I was very poor but this card have made me rich and happy, If you want to get this opportunity to become rich and establish your business then apply for this Master card, I am so happy about this because i got mine last week and I have used it to get $240,000.00 dollars from THOMAS FREDDIE UNLIMITED Hackers is giving out the card just to help the poor and needy and they ALSO OFFER FINANCIAL ASSISTANCE. get yours from THOMAS FREDDIE UNLIMITED HACKERS today. Kindly contact them by Email thomasunlimitedhackers@gmail.com

    Thank You and God bless

    ReplyDelete
  61. Are you in need of finance? we give out guarantee cash at 3% interest rate. Contact us on any kind of finance now: financialserviceoffer876@gmail.com whatsapp Number +918929509036 Dr James Eric Finance Pvt Ltd

    ReplyDelete
  62. GET RICH WITH BLANK ATM CARD ... Whatsapp: +18033921735

    I want to testify about Dark Web blank atm cards which can withdraw money from any atm machines around the world. I was very poor before and have no job. I saw so many testimony about how Dark Web hackers send them the atm blank card and use it to collect money in any atm machine and become rich. ( darkwebblankatmcard@gmail.com ) I email them also and they sent me the blank atm card. I have use it to get 90,000 dollars. withdraw the maximum of 5,000 USD daily. Dark Web is giving out the card just to help the poor. Hack and take money directly from any atm machine vault with the use of atm programmed card which runs in automatic mode.

    Email: darkwebblankatmcard@gmail.com
    Text & Call or WhatsApp: +18033921735

    ReplyDelete
  63. My names are Julia moreton I’m a citizen of UK, My younger sister was sicking of
    breast cancer and her name is Florence   I and my family have been taking her
    to all kind of hospital over here(UK) still yet no good result. I decided to go to
    the internet and search for cancer cure so that was how I find a lady
    called Sophia Charlotte,   she testifies to the world about the goodness of a
    herbal man who has the roots and herbs to cure all kind of disease and the
    herbal man email was there. So I decided to contact the herbal man @ kokobiherbalremedycentre@gmail.com for my
    younger sister to see if he can cure her from the ailment that has befallen her(breast cancer). I contacted him and told him
    my problem he told me that I should not worry that my sister will be
    cure, he told me that there is a medicine that he is going to send give to me to cook and give it to my sister to drink for one week, so I ask how
    can I receive the cure that I am in UK, he told me
    That I will pay for the delivery service. The courier service can
    transport it to me so he told me the amount I will pay, so my dad paid for
    the delivery fee. two days later I receive the cure from the courier
    service so I used it as the herbal man instructed me to, before the week runs out, my sister cancer was healed and it was like a dream to me not
    knowing that it was physical I and my family were very happy about the
    miracle of Doctor kokobi. my dad wanted to pay him 5 million  dollars as token of our appreciation towards his good work but the
    herbal man declined the offer which I don't know why, he only say that I should tell the world about him
    and the miracle he perform so am here now to tell the world about him if
    you or your relative is having any kind of disease that you can't get a solution to from
    the hospital please contact kokobiherbalremedycentre@gmail.com or WhatsApp him
    +254746618873 or call him via his calling line +2348114448587 . And if you need more information about the doctor you can send me an mail @
    juliamoreton78@gmail.com@gmail.com 

    ReplyDelete
  64. This is so amazing article i will do appreciate you work .thanks sharing information with us . you can also benefit QuickBooks Accounting software at quickbooks support phone number

    ReplyDelete
  65. Hello viewers around the Globe, I was despondent because i had a very small penis, about 2.5 inches soft and 4 inches hard not nice enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. I saw some comments on the INTERNET about this specialist called Dr.OGEDEGBE and decided to contact him on his email: dr.ogedegbe6@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement was surprised when she said that she is satisfied with my sex and i have got a large penis. Am so happy, thanks to Dr OGEDEGBE I also learned that Dr OGEDEGBE also help with Breast Enlargement Hips and Bums Enlargement etc.. If you are in any situation with a little Penis, weak ejaculation, small breast_hips_bums do get to Dr OGEDEGBE now for help on his email (dr.ogedegbe6@gmail.com) or add him on whats app line +2348109374702..............
    HE ALSO CURE THE FOLLOWING ........ HERPES VIRUS........... HPV VIRUS........ WEAK ERECTION ............
    . PREMATURE EJACULATION.............
    . LOW SPERM COUNT.....................

    ReplyDelete
  66. This comment has been removed by the author.

    ReplyDelete
  67. your article most beneficial for me .i m waiting other article. thanks for sharing with us you can also get information about it quickbooks customer service

    ReplyDelete
  68. This is so amazing article thanks for sharing this type useful wonderful information please share in future again and again .if you are looking accounting service you can get by this at

    QuickBooks customer service

    ReplyDelete
  69. As a Professional in vat registration services, providing accounting, auditing and taxation services affordably, i am sure this will hep you.

    ReplyDelete
  70. I know this could be disrespectful but i would still share my testimony with you all whom would also need same help, i got married to my wife 3 years ago until i came across DR AZIBA we could not have a child because my Penis was too small to perform and could not erect, this almost cost me my marriage, i wept in close door, no help coming , so i went online for a helpful research and i came across a review written about DR. AZIBA who prepares PENIS ENLARGEMENT PRODUCT and his contact details were also written on how he prepares root and vegetables natural product to help grow penis lenght , so i applied and he send it to my address and instruct me on how to use, within the period of (7days) my penis is already growing from 3:5 to 6:5 and DR made it known to me that i can stop when am satisfied with the result, my dear friends this is worth celebrating and sharing with my fellow men same goes to women who needs this for there man, i will write down his contact details so you all can contact the DR AZIBA as well.
    WhatsApp: +2348100368288
    Email: Priestazibasolutioncenter@gmail.com

    ReplyDelete
  71. i advise anyone looking for a forex and crypto trader in terms of account mentorshp to reach out to Mrs Thomas Mary for she has really help me know the better part of trade. I have made a lot of profit with her guidiance. you can reach her on her email adress thomasmary4554@gmail.com or reach her on her whatsapp +447508347797.

    ReplyDelete
  72. I got a blank ATM card to withdraw $5k daily for six months. I am so happy about this because i got the cloned atm card after i was scammed twice by fake hackers. I have used the card to withdraw $420k so far. Georg Bednorz Hackers is giving out the cards to help the poor and needy though it is illegal but it is something nice. No one gets caught when using this card. you can get it from Georg Bednorz Hackers today! He is kind, lovely, humble. Also, Georg Bednorz is an expert crypto trader through his trading signals, i made $1 million bitcoins, doubling my profit in 3 weeks.
    Contact Email: georgbednorzhackers@gmail.com
    WhatsApp/Text: +12623558285

    ReplyDelete
  73. How can I explain this to the world that there is a man who can cure HERPES, I was diagnosed for the past 5 mouth I have being into HERPES since 5 mouth, so I decide to look for help in the internet then I found a post write about this great man called Dr Kibaki , people say good thing about him that this man have cured, a lot of people in the internet, him has power's to cure HSV1 AND HSV2 I don’t believe that there is a cure for Herpes Simplex Virus because though there is no cure for herpes that what I have in mind HERPES had no cure well , my HERPES is negative through the using of herbal cured of dr Ojoka, I contacted this man for help because of what i see in the internet. if you need his cured just email him now on drkibakisolutiontemple@yahoo.com , thank you DR. i will never stop shearing you testimony Dr Kibaki . him Can as well CURE THE FOLLOWING DISEASE:-1, HIV/AIDS, 2, Diseases of the hear 3, Malignant tumors 4. Cardiovascular diseases 5. Diabetes mellifluous 6.Influenza and pneumonia 7.Alzheimer's disease 8. hsv1 - hsv2. You can also reach Dr. Kibaki on his email: drkibakisolutiontemple@yahoo.com or call : +1 860 397-2711

    ReplyDelete
  74. UBL Business Setup in Dubai provides businesses and entrepreneurs with the greatest consultation and essential tools to build, support, and enhance the company's work and papers, with over a decade of experience. We can address issues that no one else can because of our size, reach, and skill. Company Registration in Dubai, PRO services, trade license acquisition services, visa services, and insurance services are all available to help you start your business in Dubai.

    ReplyDelete
  75. Hello Everyone out there,I am here to give my testimony about a Herbalist doctor who helped me . I was infected with HERPES SIMPLEX VIRUS in 2011, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. One day I was in the river side thinking where I can go to get solution. so a lady walked to me telling me why am I so sad and i open up all to her telling her my problem, she told me that she can help me out, she introduce me to a doctor who uses herbal medication to cure HERPES SIMPLEX VIRUS and gave me his email, so i mail him. He told me all the things I need to do and also give me instructions to take, which I followed properly. Before I knew what is happening after two weeks the HERPES SIMPLEX VIRUS that was in my body got vanished . so if you are also heart broken and also need a help, you can also email him at {oliha.miraclemedicine@gmail.com}
    or whatsapp him number: +2349038382931. or website is https://olihamiraclemedicine.webs.com/

    Contact him today and you will have a testimony...Good luck!

    Dr. OLIHA Also Cures:
    1. HIV/AIDS
    2. HERPES 1/2
    3. CANCER
    4. ALS (Lou Gehrig’s disease)
    5. Hepatitis B
    6. chronic pancreatic
    7. Emphysema
    8. COPD (Chronic Obstructive Pulmonary Disease

    ReplyDelete
  76. Endeavor Corporate Services LLC is committed to helping customers seamlessly develop their mainland business setup in Dubai, United Arab Emirates (and Ajman Free Zone). To this end, we help them obtain business licenses, local sponsorship agreements, office space, PRO services, accounting, website development, etc. in just one day. Our expertise is complete business solutions, free consultation on business formation, and 100% successful documents. The vision and mission is to become the preferred business setting service provider in Dubai mainland and the best PRO service in Dubai, and strive to help our customers in all aspects of business setting in Dubai, UAE.
    https://endeavourbiz.com/

    ReplyDelete
  77. 12 Panel Now provides Drug Tests in Bulk! FDA and CLIA waived drug test kits, urine drug test strips + HCG Pregnancy Tests, Fast and Accurate!

    ReplyDelete
  78. DO YOU NEED A PERSONAL/BUSINESS/INVESTMENT LOAN? CONTACT US TODAY VIA WhatsApp +19292227023 Email drbenjaminfinance@gmail.com

    HELLO
    Loan Offer Alert For Everyone! Are you financially down and you need an urgent credit/financial assistance? Or are you in need of a loan to start-up/increase your business or buy your dream house. Are you in search of a legit loan? Tired of Seeking Loans and Mortgages? Have you been turned down by your banks? Have you also been scammed once? Have you lost money to scammers or to Binary Options and Cryptocurrency Trading, We will help you recover your lost money and stolen bitcoin by our security FinanceRecovery Team 100% secured, If you are in financial pains consider your financial trauma over. We Offer LOANS from $3,000.00 Min. to $30,000,000.00 Max. at 2% interest rate NO MATTER YOUR CREDIT SCORE. GET YOUR INSTANT LOAN APPROVAL 100% GUARANTEED TODAY VIA WhatsApp:+19292227023 Email: drbenjaminfinance@gmail.com


    ReplyDelete
  79. 12 Panel Now Offers Drug Tests, drug test kits, and drug tests at low prices.
    12panel Now Offers Drug Tests in Bulk at Low Prices. we offer a variety of tests that detect many types of drugs. We offer 12 Panel Urine Drug Tests, Drug Test Strips, Drug Test Cups, Drug Test Cartridges, Dip Cards, Oral Swabs Tests, and more. We also provide drug tests in bulk quantity or for single-use home tests at low prices.

    ReplyDelete
  80. Investing online has been a main source of income, that's why knowledge plays a very important role in humanity, you don't need to over work yourself for money.All you need is the right information, and you could build your own wealth from the comfort of your home!Binary trading is dependent on timely signals, assets or controlled strategies which when mastered increases chance of winning up to 90%-100% with trading. It’s possible to earn $10,000 to $20,000 trading weekly-monthly, just file a complaint with Mr. William, I had almost given up on everything about binary trading and ever getting my lost funds back, till i met with him, with his help now i have my lost funds back to my bank account and I can now trade successfully with his profitable strategies and software!! Email: GLOBALFXINVESTMENT3@GMAIL.COM

    ReplyDelete
  81. I'm Tom Kingsley,USA.It's been a while since I've
    written to thank Dr OHIKHOBO who helped me in my
    life. I was infected with HERPES SIMPLEX VIRUS in 2016, i went to many
    hospitals for a cure but there was no solution, so I was thinking how can I
    get a solution out so that my body can be okay. One day my Aunt Rosa
    introduce me to Doctor OHIKHOBO having seen so many testimony online
    about his herbal medication to cure HERPES and gave me his
    email:drohikhoboherbalcenter@gmail.com , so I emailed him. He told me all the
    things I needed to do and also gave me instructions to follow, which I
    followed properly. Before I knew what was happening after one weeks the
    HERPES that was in my body vanished. so if you are you are having
    herpes or any kind of disease listed below
    *DIABETES
    *CANCER
    *STROKE
    *INFERTILITY
    *HEART DISEASE
    *HIV
    *COLD SORES
    *GENITAL WARTS
    And you also want cure, you can also email him at:drohikhoboherbalcenter@gmail.com or through his WhatsApp +2348103601042

    ReplyDelete
  82. I thought this article is the great way to explain everything about the leadership and latest biotechnology knowledge to children. thanks for sharing. i would appreciate more your blog

    ReplyDelete
  83. i there I am so happy to stumble upon your weblog, I really found you by accident,
    while I was researching on google for contract research organization, Regardless I am here now and would just like to say thank you for a fantastic post and a all round educaional blog , i learn lot on Drug discovery servicesI don't have time to go through it all at the minute but I have saved it and also added your RSS feeds, so when I have time I can revisit your page, Please do keep up the excellent job.

    ReplyDelete
  84. months ago I felt some pains and I went to the hospital my doc told me I had Herpes about 1 year ago and I need to start the treatment early, he gave me some medicine to be taking and I told him no I’ll not, because I hated taking medicine when I won’t not see cure for the purpose. After I got home I started getting worried searching for strong advice and I found valid natural treatment online a lot of people says they got herpes cure from DR ODUDU and I contacted DR ODUDU that same day I purchase his cure online, after three weeks of taking the herbal treatment i got cured totally. i tested negative all thank to DR ODUDU you can reach out to him through his email: [dr.oduduherbalhome@gmail.com ] or message him on WhatsApp +2348101571054 stay safe and bless you

    ReplyDelete
  85. Gooday, everyone, my name is Brunetti Keller. I live in the United States. I met doctor Egobe through my friend Perry Maggie. This is her phone number (815)570-3923...god in his mercy will help me bless doctor Egobe. he gave me joy and happiness in my darkest days. He is the most miraculous herbal man I have ever come across. I was a victim of a deadly disease and he cured me. If you have any disease and you think that there is no cure, contact him with this email address; dregobeherbalcure01@gmail.com or write him on WhatsApp contact +2348023357986 and your life will change forever ..
    Youtube channel https://youtube.com/channel/UCV6FRhiPpwSvRdFq9_SRAXQ  

    ReplyDelete
  86. very relevant information which we want to know it take much time to read but in the last this blog give you setisfactive information our blessings are always with you admin . from lgrespicare.in

    get Oxygen Concentrator on Rent in Delhi & NCR At Lowest Price with Free Home Delivery Call : 9810306003


    ReplyDelete
  87. Thanks for sharing such a piece of useful information among us.

    IVF Smart provides the opportunity to start a family. Through our access point, families around the world are able to attain in Vitro Fertilization (IVF) and other ART products at an affordable price. We focused on distributing IVF & Fertility Medications directly to your doorstep. We are 100% committed to making sure we make the process of IVF easier and less costly for you.

    Buy Menopur
    Buy cetrotide
    Gonal F price

    ReplyDelete
  88. Vat Registration Dubai


    Still Seeking How to do VAT Registration UAE ? Registration of VAT , UAE VAT Registration , Online VAT Registration , VAT Registration Dubai.

    ReplyDelete
  89. thank you for sharing . good knowledge sharing in this post.Derma Medicine Company is a trusted Pharma Company for the Dermatology range. We offer the Derma cosmetic companies in india Derma Franchise Company at pan India level. This is the best Derma PCD Pharma Franchise company that provide high quality range of Derma Products.

    ReplyDelete
  90. Am short of words for the amazing profit you helped me earn in just a week with binary options strategy am so sorry I doubted at the beginning, I invested $200 and earn $2,500 in just one week, and kept on investing more, today I am financially successful, you can contact him via Email: (tdameritrade077@gmail.com) whatsapp(+447883246472) I advice you shouldn't hesitate. He's great.

    ReplyDelete
  91. Do you need a solution for male infertility like: AZOOSPERMIA, LOW SPERM COUNT, WEAK ERECTION, and PREMATURE EJACULATION? Look no further! Dr. Uduehi has the cure/remedy to any type of male infertility. It’s been 4 months since he cured me of azoospermia and my spouse is currently pregnant for me. I was diagnosed of Non-obstructive azoospermia (NOA), which people believes it’s impossible to be cured or treated. But with Dr Uduehi’s medication, I got cured. I am expecting a baby anytime soon and I was introduced to the doctor by someone whom he treated of low sperm count. So, I deemed it fit to share my experience with the doctor to the general public and to give hope to those who don’t know who to meet for their problems. The doctor’s contact: (uduehiherbalcare@gmail.com) (+2347084878384)

    ReplyDelete
  92. Hello
    We are professional traders, earning on forex and binary for investors weekly, will love to tell you all more about our investment platform where you can invest funds as little as $500 and start earning $5,500 weekly, alot of people has benefited from this investment offer before and during this convid-19 virus, if you passing through financial difficulties due to this coronavirus and you need help paying bills simply choose a suitable investment plan for yourself and start making profit weekly $500 to earn $5,000 in 7 days
    $1000 to earn $10000 in 7 days
    $5000 to earn $50000 in 7 days To Start your investment now contact Via whatsapp: +1 (512) 975 2877 or email ✉️contact@koinbuzzcompany.com

    ReplyDelete
  93. I am amazed by Ohikhobo's remedy. I Have had herpes for over 6 years with frequent outbreaks. Sometimes I average 2-3 times per month. Before one breakout could end, the next would begin. Nothing has helped me. I came online in search for a possible way to see how I can fight this virus so I found Ohikhobo here online after seeing a lot of testimonies of how he cured herpes and other diseases with natural herbs so I decided to give it a try I only took his remedy for two weeks and I was completely cured. I recommend Ohikhobo's remedy to anyone suffering from herpes that wants to be completely cured too.

    Email: drohikhoboherbalcenter @ gmail com

    WhatsApp +1740-231-2427

    ReplyDelete
  94. I want to thank Mrs Carroll Walker loan firm for giving me a loan of 4,000.00 euro. If you need a quick loan avoid being scammed by fake lenders and apply from a genuine loan company I told myself that any Loan lender that could change my Life and that of my family after being scammed severally by these online loan lenders, I will refer the person to Mrs Carroll Walker loan firm who gave me and my family happiness, although at first I found it hard to trust her because of my experiences with past loan lenders, I was in need of a loan of 4,000.00 euro to start my life all over as a single parent with 2 kids he is indeed a GOD fearing woman, working with a reputable loan company. If you are in need of a loan and you are 100% sure to pay back the loan please contact her oail infoloanfirm20@gmail.com

    ReplyDelete
  95. Invest with a well known company where you will have access to create and fund your account yourself, have full access to be monitoring your trading, how your profit goes ,and at the end of every successful trading, you can place your withdrawal requests to your bank account or bitcoin wallet with no stress. I am a living witness. With Mrs Roberts , trading is made easy.
    Here is a possible link to contact her:
    email>robertslee618@gmail.com.
    Whatsapp> +44 7424 297663.

    ReplyDelete
  96. Hello everyone... Dr Ishiaku herbs is a good remedy for herpes Virus , I was a carrier of herpes virus and I saw a testimony on how Dr. Ishiaku cure Herpes Virus, I decided to contact him, and he guided me. I asked him for solutions and he started the remedies for my health. After he finish he sent me the herbs which i took for 2 weeks before asking me to go for a check up and getting there i could not believe that i was confirm HSV 2 Negative after the test, Today i am so happy because I'm free from herpes disease with the help of Dr. Ishiaku . Thank God now everything is fine, I'm cured by Dr. Ishiaku herbal medicine, I'm very thankful to God for making it possible. you can reach him on his email, i strongly recommend him to any one out here looking for a cure to herpes or any other deadly disease...Contact Dr ishiaku via email: ishiakuherbalcure@yahoo.com or whats-app +2348180828544

    ReplyDelete
  97. I thought this blog is the great way to explain everything about the leadership and latest biotechnology knowledge and also the investment opportunity. Thanks for sharing. i would appreciate more your research.

    ReplyDelete
  98. hello everyone i am bruce from Texas USA. I want to share a testimony of how Dr. Aluya herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr. Aluya. herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and contacted him through his email, draluyasolutionhome@gmail.com, and he replied me and I did what he ask me to do, and to my greatest surprise in less than two weeks of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 11 inches and i do not have weak erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. EX LOVER BACK/BOYFRIEND/HUSBAND/WIFE/GIRLFRIEND PREMATURE EJACULATION LOW SPERM COUNT ERECTILE DYSFUNCTION HIV/AIDS CURE HERPES CURE INFECTION CURE PILE STROKE HEART FAILURE CANCER
    You can contact him draluyasolutionhome@gmail.com you can contact him today through his whatsapp or call +2348137317157

    ReplyDelete
  99. hello everyone i am PAWN JACKSON from Texas USA. I want to share a testimony of how Dr. Aluya herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr. Aluya. herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and contacted him through his email, draluyasolutionhome@gmail.com, and he replied me and I did what he ask me to do, and to my greatest surprise in less than two weeks of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 11 inches and i do not have weak erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. EX LOVER BACK/BOYFRIEND/HUSBAND/WIFE/GIRLFRIEND PREMATURE EJACULATION LOW SPERM COUNT ERECTILE DYSFUNCTION HIV/AIDS CURE HERPES CURE INFECTION CURE PILE STROKE HEART FAILURE CANCER
    You can contact him draluyasolutionhome@gmail.com you can contact him today through his whatsapp or call +2348137317157

    ReplyDelete
  100. Excellent article. If someone is looking for old age people physiotherapy in Bhopal city, you can check here
    Old Age People Physiotherapy in Bhopal

    ReplyDelete
  101. I read your blog post, your blog post having lots of fun about drugs Jeremy but my question It's better than drugs Jeremy . I read some other blog posts but your content is fully informative. I appreciate your work keep it up

    ReplyDelete
  102. Buy IVF medication at affordable prices, save up to 70%- LIVE IVF

    Buy Merional
    Gonal F price

    ReplyDelete
  103. THE MAN GOD SENT TO HELP ME IS DR EBOSELE.

    It is said that when someone has done good for you he or she has to be appreciated this is why i am here to appreciate and share a good news about DR EBOSELE for curing me from the Genital Herpes. i have been dealing with HSV1 AND SINCE 2019 until 2021 when i come to contact the God sent man DR EBOSELE who gave 2 weeks treatment and suddenly all the pox on my skin left and am herpes free with the cure from EBOSELE SOLUTIONS . with this great happiness in my heart i wanna ask ya all to join me thank him and if anyone need help to cure any kind of disease or anything prayers kindly contact him today via his details below:
    Email; eboselesolutions@gmail.com,
    Whatsapp/call; +2348146646995
    cureforherpesnow665.blogspot.com

    ReplyDelete
  104. HOW TO RECOVER YOUR LOST FUNDS STOLEN BY SCAM ON LINE I made several successful investments with this broker before losing 40% of my savings to the trading scam. It cost me so much money and pain to invest in an investment that was not even real. I was able to recover the majority of the funds, and we are still attempting to recover the rest. I highly recommend SECURE TO INVEST WELL for anyone involved in an online trading scamTrading scam$350,000 recovered                                 
    BELOW  IS THEIR CONTACT:secure2investwell@gmail.comcall/whatsapp: +14638887391

    ReplyDelete
  105. I want to share a testimony of how Dr Aluya herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr godfather herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him draluyasolutionhome@gmail.com or or call or what-apps him through (+2348137317157).he also specialize on the following things
    1. HIV / AIDS
    2. HERPES 1/2
    3. CANCER
    4. ALS (Lou Gehrig's disease)
    5. Hepatitis B
    6. chronic pancreatic
    7. emphysema
    8. COPD (chronic obstructive pulmonary disease)
    Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful
    Contact him now on email drAluyasolutionhome@gmail.com or via WhatsApp (+2348137317157)

    ReplyDelete
  106. Lord Bubuza is like a God on Earth, I have seen and experienced the reason why people call him a God on Earth, I never believed that men like him existed. I contacted lord Bubuza for help via WhatsApp: +1 984 240 7211 to win a lottery after reading different testimonies on the internet on how he predicted lottery winning and gave winning numbers to people to play and they won. He responded and said that he would cast a spell to predict my winning, I provided his requirements and did as he instructed. After casting the spell he gave me some numbers and a lottery website where to play the lottery game. After playing as he instructed I won $781,999,000 Euro. This man has made my life beautiful with his lottery winning number. I have made a vow to myself that I will testify of his miraculous spell for making me a millionaire. Contact lord Bubuza via WhatsApp: +1 984 240 7211 or e-mail: lordbubuzamiraclework @ hotmail . com

    ReplyDelete
  107. I read your blog, the provided information is very useful for computer aided drug designing. Keep continue to posting further.

    ReplyDelete
  108. HOW I MADE THOUSANDS OF DOLLARS WITH $1,000 VIA BITCOIN TRADING EXPERT

    It's been more than a month of constant happy returns from all the investments I have made with David Benjamin. My first investment of $1,000 got me $9,300 in an amazing few days. I saw a few reviews and decided to add mine to inspire someone to make that right decision to invest and trust this expert trader with skills and enhanced software to navigate the market. Contact on davidbenjaminexptrader@outlook.com or on WhatsApp +1 408 500 0775

    ReplyDelete
  109. HAVE YOU LOST YOUR MONEY TO BINARY OPTION SCAM OR ANY ONLINE SCAM WHATSOEVER?.DO YOUR DESIRE CREDIT REPAIR[EQUIFAX, EXPERIAN, TRANSUNION? WELL, YOU HAVE FOUND REDEMPTION.


    BEWARE OF FRAUDSTARS looking to hoax.
    if you have been a VICTIM, contact
    :Email:creditcards.creditscoreupgrade@gmail.com
    :whatsapp:+1785 279 3047 for directives.
    Here, it's always a win for you.

    ��OUR SERVICES��
    Binary Option funds recovery
    Social media hack
    Recovery of loan scam
    Credit repair (Equifax,Experian,Transunion)
    E mail hack
    College score upgrade
    Android & iPhone Hack
    Website design
    Website hack
    And lots more.

    CONTACT INFO:
    Email:creditcards.creditscoreupgrade@gmail.com
    whatsapp:+1785 279 3047
    Copyright ©️ 2022.

    ReplyDelete
  110. TTTTHAVE YOU LOST YOUR MONEY TO BINARY OPTION SCAM OR ANY ONLINE SCAM WHATSOEVER?.DO YOUR DESIRE CREDIT REPAIR[EQUIFAX, EXPERIAN, TRANSUNION? WELL, YOU HAVE FOUND REDEMPTION.


    BEWARE OF FRAUDSTARS looking to hoax.
    if you have been a VICTIM, contact
    :Email:creditcards.creditscoreupgrade@gmail.com
    :whatsapp:+1785 279 3047 for directives.
    Here, it's always a win for you.

    ��OUR SERVICES��
    Binary Option funds recovery
    Social media hack
    Recovery of loan scam
    Credit repair (Equifax,Experian,Transunion)
    E mail hack
    College score upgrade
    Android & iPhone Hack
    Website design
    Website hack
    And lots more.

    CONTACT INFO:
    Email:creditcards.creditscoreupgrade@gmail.com
    whatsapp:+1785 279 3047
    Copyright ©️ 2022.TTT

    ReplyDelete
  111. My name is Mr Smith kamogelo kekana

    I want to share to the world this testimony how Dr Siya helped me cure my ilness with his herbs.



    I must confess i never believed it will work because i was introduce to him by my friend who was cured of hepatitis B  by Dr Siya from South Africa, I will advise you all who is looking for a cure to their ilness should contact  him using details below, After 7days of taking the herbs he prepared and sent to me i tested negative.Facts proven that God has provided us with everything we need to survive this harsh world naturally/Herbally.

    God heals with man prepared herds i urge you not to give up until you get cured



    NB: Dr Siya cure any kind of cancer/illness Etc. he heals with natural herbs.

    i urge you to contact him Email: (siyabongambeuherbalguru@gmail.com)


    WhatsApp: +27717578375

    God Bless You And Heal You Amen!

    ReplyDelete
  112. Hello everyone,
    I have seen a few reviews online about making profit from crypto currency trading but I am here to introduce you to a genuine, fast and reliable way to make guaranteed profits in less than 8 days. I was having some financial challenges less than 2 months ago and I got introduced to an expert trader by my colleague from work who had earlier talked about making some fast money from crypto trading, and i made an initial investment deposit of $1,000 and in a few days i got a return on investment of about $8,700, i was amazed at the swift and safe nature of trading employed by this qualified trader. I did engage in a bigger investment and that was what blew my mind, made over $22,000 in another few days, trust me when i say my life has changed for the better. This has been my ticket to financial stability, and i thought of sharing this wonderful investment opportunity to those who will take the leap of faith to be blessed. I will drop the contact info;

    WhatsApp: +1 408 500 0775
    Email : davidbenjaminexptrader@outlook.com

    ReplyDelete
  113. Nice Post
    You provide good information and keep updating. We are providing some services. Please Check it.
    Top 3D design and stand building in Germany
    Trade show management in Europe

    ReplyDelete
  114. HOW I MADE THOUSANDS OF DOLLARS WITH $1,000 VIA BITCOIN TRADING EXPERT
    It's been more than a month of constant happy returns from all the investments I have made with David Benjamin after a saw a review on Quora. My first investment of $1,000 got me $9,300 in an amazing few days. I saw a few reviews on here and decided to add mine to guide and inspire someone to make that right decision to invest and trust this expert trader with skills and enhanced software to navigate the market. Contact on davidbenjaminexptrader@outlook.com or on WhatsApp +1 408 500 0775

    ReplyDelete
  115. I lost my job few months back and there was no way to get income for my family, things was so tough and I couldn't get anything for my children, not until a met a recommendation on a page writing how Mr Bernie Wilfred helped a lady in getting a huge amount of profit every 6 working days on trading with his management on the cryptocurrency Market, to be honest I never believe it but I took the risk to take a loan of $1000. and I contacted him unbelievable and I was so happy I earn $12,500 in 6 working days, the most joy is that I can now take care of my family I don't know how to appreciate your good work Mr. Bernie Doran God will continue to bless you for being a life saver I have no way to appreciate you than to tell people about your good services.
For a perfect investment and good strategies contact Mr Bernie Doran via WhatsApp :+1(424)285-0682 or Telegram : @Bernie_doran_fx or Email : Bernie.doranfx01@gmail.com

    ReplyDelete
  116. Hello everyone My name is alex smith am from California i am here to give a testimony on how I join the illuminati brotherhood, I was trying to join this organization for so many years now,I was scammed by fake agent in south Africa and Nigeria,I was down,I could not feed my self and my family anymore and I tried to make money by all miss but all invail, I was afraid to contact any illuminati agent because they have eat my money,One day I come across a post of someone giving a testimony, thanking a man calld noah robert of being helping me to join the illuminati brotherhood, then I look at the man email and the phone number that was written there, it was a Germany number I was afraid to contact him because a nigerian agent eat my $6000 and go away with the money then I was very tired, confused and I decided to contact the person that was given the testimony and i called him and I communicated with him on phone calls before he started telling me his own story about when he wanted to join, he told me everything to do, then I made up my mind and message the agent called noah robert and he told me everything to do, and I was initiated, surprisely I was given my benefit of being a new member of the great illuminati brotherhood I was so happy, For those of you trying to join this organization this is your opportunity for you to join CONTACT MR noah robert WhatsApp him on +4915217824272 or email.noahrobert890@gmail.com

    ReplyDelete
  117. Wow, that's what I was trying to find, what things! Present below on this site, thanks to the admin of this site.
    Also learn our website business consulting firms

    ReplyDelete
  118. WELCOME TO THE ILLUMINATI BROTHERHOOD ORGANIZATION.


    I believe we all have a dream, a dream to become something big in life, so many people die today without accomplishing their dreams. Some of us are destined to become the president of our various countries or to become. one of the world's greatest musicians, footballers, politicians, businessmen, comedians or to be a helper to other people that are in need Note; newly recruited members are entitled to great benefits and rewards, There is no human sacrifice. If you are truly interested in joining the illuminati contact us today for more Information WhatsApp: +1 (510)-900-9125

    ReplyDelete
  119. Nice blog and absolutely outstanding. You can do something much better but I still say this perfect. Keep trying for the best.

    List of Best Gynae Products Franchise Company in India
    List of Best Gynae Products Franchise Company in India

    ReplyDelete
  120. That is really an informative post . Genscript probio offers a one-stop service for single B cell screening and antibody humanization. To know more about our services, contact us now.

    ReplyDelete
  121. Dr AZIBA, Herbal Remedy Product is 100% guarantee for Pennis Enlargement growth and Thickness you can Contact him via Email: PRIESTAZIBASOLUTIONCENTER@GMAIL.COM For Best natural male enhancement Product with 100% guaranteed results. He prepares top Herbal selling male enhancement product with herbal formula and no side-effects And also for other Disease or virus such as Prostate Cancer, HIV, HERPES, HEPATITIS, DIABETES, CANCER etc.. Contact DR WhatsApp +2348100368288

    ReplyDelete
  122. I want to express how grateful I am to CYBERCRDITGURU a credible and reliable hacker who helped recovered the $45,000 I lost to scammers online and also hacked into my cheating husband’s mobile phone and social media accounts. I am married with 3 kids although my husband is extravagant and cheats on me with a lot of side chicks, he hardly comes home. Then I saw this investment platform online and decided to invest the sum of $45,000 to it, with the intention to grow it but I never got my money back neither capital nor profit. “I was scammed”. However, I discovered CYBERCREDITGURU through positive reviews read on MerchantCircle and reached out to them immediately on CYBERCREDITGURU (AT) GMAIL DOT COM and phone/text: +1 (650) 439 0624 and they helped recovered my lost $45,000 and helped me monitor my husband’s calls and social media accounts. I now have my husband back. I can’t thank them enough but give them a 5-star review as a token of my sincere appreciation. I strongly recommend them to anyone with related issues. Here is there contact again: CYBERCREDITGURU (AT) GMAIL DOT COM and phone/text: +1 (650) 439 0624

    ReplyDelete
  123. I was scammed of $220,000 worth of bitcoin with a scam forest investment unknowingly then I didn’t know what to do.. I felt like I should committed a suicide but I fortunately have a good start again until my friend introduced me to a fund recovery specialist named Gray walker who helped to recovered my lost funds in just few days, if you feel scammed with fake forex you don’t need to be worried you can also text him on Email: graywalker92@gmail.com

    … and he will recover your bitcoins back...
    Text/WhatsApp : ‪+1 (409) 509‑0612

    ReplyDelete
  124. I'm here to applaud the good work of Dr Amber that has really been wonderful doing good with his magical spells. I usually play the lottery but coming up with a big win has never been my thing not until I came in contact with Dr Amber who a lot of people have been so thankful to for his miraculous doings. I told Dr Amber that I needed to win the Lottery in a big way that Lottery winnings have never favored me from the very start. He explained to me that not everyone is luckily blessed to win the Lottery but with his spells, he can make me a Lottery winner and I agreed to what he said. He prepared the spell for me and told me the exact ticket to pick that made me a winner of £180,000,000 MILLION POUNDS. I made sure Dr Amber had 10% from my winnings because indeed his spells are magnificent. Thank you sir for all you do. Anyone out there that needs help in any area of life can Email Dr Amber via: amberlottotemple@yahoo.com or amberlottotemple@gmail.com or go to: amberlottotemple.com

    ReplyDelete
  125. Thanks for the sharing valuable information. If you have any doubts regarding business setup in dubai contact us.

    ReplyDelete
  126. I was scammed for a huge amount of money, devastated I started to search for help. Someone referred an expert and private investigator, Optimus. I emailed him and as soon as I explained what had occurred he told me immediately that it was all a scam. He gathered my case together and within a few days we got a result and I got all of my money back! Optimus was amazing, professional and efficient, he guided me through the whole experience. I cannot thank him enough – I can now live again! His mail info is Recoverbtchelp07 at gmail DOT COM
    Whatsapp or text: +1 315 784 1311

    ReplyDelete
  127. Investing online has been a main source of income, that's why knowledge plays a very important role in humanity, you don't need to over work yourself for money.All you need is the right information, and you could build your own wealth from the comfort of your home!Binary trading is dependent on timely signals, assets or controlled strategies which when mastered increases chance of winning up to 90%-100% with trading. It’s possible to earn $10,000 to $20,000 trading weekly-monthly in cryptocurrency(bitcoin) investment,just get in contact with Mr Bernie Doran my broker. I had almost given up on everything and even getting my lost funds back, till i met with him, with his help and guidance now i have my lost funds back to my bank account, gained more profit and I can now trade successfully with his profitable strategies and software!! 
Reach out to him through Gmail : Bernie.doranfx01@gmail.com ,Telegram: bernie_doran_fx or +1(424)285-0682 for inquires

    ReplyDelete
  128. Superb b서천출장샵
    청양출장샵
    홍성출장샵
    예산출장샵
    태안출장샵log. When I saw Jon’s email, I know the post will be good and I am surprised that you wrote it man!
    We are the best Share Market training academy in Chennai, offering best stock market trading and technical analysis training online & live classes. Enroll now for share market classes by today.for more details contact us

    ReplyDelete
  129. Hello, thank you for the information. I have been able to obtain new information here. However, I use this page to specialize in some technical problems. I have reloaded the page many times, so I was able to load it correctly. I wonder if your web host was OK.안성출장샵
    부천출장샵
    남양주출장샵
    포천출장샵
    수원출장샵
    성남출장샵
    안산출장샵

    ReplyDelete
  130. There are different ways at which you can invest in an online platform and make an extra cash. Usually people get to loose their money to fake binary option, which there is a leading solution to that now. Peradventure you invested in the wrong trading platform and you search for a way to recover your scammed funds. Contact George now via email Cryptorefunder360(at)gmail(dot)com or whatsapp  +1 (769)899 0106.

    ReplyDelete
  131. Hello everyone, is there anyone out here looking for the perfect strategy to trade with? or tired of losing your money to brokers and software? contact (Aaron Gabriel) via: Aarongabriel310@gmail.com, or on WhatsApp +1 (314) 649-8612. he will introduce to you the perfect strategy that provides me with $10000 in a week, and also show you some proof to clear your doubts. And also how you can get back your lost funds from your brokers.

    ReplyDelete
  132. Amazing trading platform, quick withdrawal I have been using this platform together with the most recommended forex strategy on the internet from Robert and so far i have no complaints making $7000-$15000 on a weekly basis he is great and i am thankful i was lucky enough to have met him via Email Robertseaman939@gmail.com

    ReplyDelete
  133. I was scammed of $379,000 worth of bitcoin with a scam forest investment unknowingly then, I didn’t know what to do.. I felt like committing suicide, but fortunately for me, my friend introduced me to a cyber crime investigator Robert Seaman who also helps in recovering lost invested funds, After working with him, to my greatest surprise, in just few days I got all my lost funds back, and he only took just 15% out of the recovered funds, if you have been scammed with fake forex you don’t need to be scared or worried, because you can also reach him on his email: Robertseaman939@gmail.com He will recover your lost bitcoins back fast and smoothly...And you will be amazed….!!!

    ReplyDelete
  134. dlaczego usługi remontowe najfajniejsza strona internetowa o usługi remontowe warszawa

    ReplyDelete
  135. usługi remontowe warszawa kliknij tutaj to kwestia która mnie intryguje

    ReplyDelete
  136. remonty mieszkań warszawa jak wyglądają remonty mieszkań to materia jaka mnie ciekawi

    ReplyDelete
  137. kliknij tu to kwestia które mnie trapi

    ReplyDelete
  138. При выпуске мебели или внутренней отделки комнат, для создания особых тем декора, для облицовки бортов автомобилей - это только небольшой перечень использования общепризнанного водостойкого материала. Обще бытовое применение листов прочного и легкообрабатываемого материала достаточно внушительно. Фанерную плиту https://fanwood.by/ водоустойчивую используют не исключительно в морском транспорте.

    ReplyDelete
  139. remonty mieszkań warszawa tutaj to materia jaka mnie niepokoi

    ReplyDelete
  140. Наращивайте лучшие беклинки на ваш интернет ресурс и увеличьте посещаемость, Индекс качества сайта. Разбавьте текущую ссылочную массу, усиливайте обратные ссылки с бирж ссылок, пирамида ссылок, tier 1, tier 2, tier 3. Бессмертные ссылки с не спамных сайтов на ваш ресурс, экономичнее чем на биржах и аналогов на интернет рынке беклинков. Официальный сайт - https://seobomba.ru/

    ReplyDelete
  141. Влагостойкая фанера ФСФ - среда применения http://tatra114.ru/index.php?subaction=userinfo&user=acugely

    ReplyDelete
  142. kliknij super strona w temacie remonty mieszkań warszawa

    ReplyDelete
  143. Достоинства платформы Slogy http://slogy.ru/blog/disleksiya-u-detei

    ReplyDelete
  144. IsraFace - знакомства в израиле, это сообщество евреев, где зарегистрированы евреи и еврейки и русский еврей из России и США. Добавляйте какие угодно снимки, ролики, подключайтесь в сообщество, ведите блог, наведывайтесь на форум, заводите еврейские знакомства.

    ReplyDelete
  145. IsraFace - еврейские новости, это еврейская соцсеть, где находят свою любовь еврейки и евреи и русский еврей из России и Ульяновска. Добавляйте лучшие фотки, записи, подключайтесь в группы, ведите блог, наведывайтесь на форум, заводите еврейские знакомства.

    ReplyDelete
  146. https://souz-invest.ru как правильно сделать рассаду

    ReplyDelete
  147. klik tutaj moja strona www proszę sprawdzić

    ReplyDelete
  148. remonty warszawa zobacz tu to materia która mnie trapi

    ReplyDelete
  149. Ежедневное использование листов прочного и легкообрабатываемого материала максимально обширно. При выпуске мебели или внутренней отделки комнат, для производства уникальных тем декора, для облицовки бортов грузовиков - вот лишь крошечный список использования общепринятого водоустойчивого материала. Фанерную плиту водоустойчивую https://xn--80aao5aqu.xn--90ais/?product_cat=fanera-fsf применяют не только в судостроении.

    ReplyDelete
  150. remonty mieszkań warszawa remont mieszkania w Warszawie to temat jaki mnie niepokoi

    ReplyDelete
  151. tutaj wejdź najlepsza strona o remonty mieszkań warszawa

    ReplyDelete
  152. При использовании искусственной клеящей основы плиты шпона http://chinatksrubber.cn/space-uid-376911.html не изменят своей формы под воздействием дождя и снега или высокой влажности. Цена этого материала довольно низкая. По причине перпендикулярно связанных лент шпона влагонепроницаемый тип фанеры практически равен по прочности настоящей древесине.

    ReplyDelete
  153. Цивин Михаил Балет 37 лучших фото https://cojo.ru/znamenitosti/tsivin-mihail-balet-37-foto/

    ReplyDelete
  154. remonty warszawa remontowanie Warszawa to temat który mnie trapi

    ReplyDelete
  155. Warszawa i trud remontu własna strona zapraszam do sprawdzenia

    ReplyDelete
  156. remontowanie w Warszawie najfajniejsza strona internetowa o remonty warszawa

    ReplyDelete
  157. remont to myśl jakie mnie trapi

    ReplyDelete
  158. remont Warszawa z fachowcem super strona na temat remonty warszawa

    ReplyDelete
  159. remonty warszawa tutaj zobacz to sprawa jaka mnie ciekawi

    ReplyDelete
  160. remonty warszawa sprawdź tutaj to przedmiot jaki mnie niepokoi

    ReplyDelete
  161. tutaj wejdź super strona internetowa na temat remonty warszawa

    ReplyDelete
  162. remonty mieszkań warszawa tutaj to temat jaki mnie ciekawi

    ReplyDelete
  163. wykończenia wnętrz warszawa wykończenie wnętrz w Warszawie to sprawa jaka mnie niepokoi

    ReplyDelete
  164. wejdź tutaj najlepsza strona www o wykończenia wnętrz warszawa

    ReplyDelete
  165. Продукция сменные кассеты gillette купить оптом, это отличный способ начать свое дело. Постоянные акции на лезвия gillette fusion. Средства для бритья триммер-лезвие fusion функциональные комплекты gillette купить оптом по оптимальной цене производителя. Хорошая возможность купить джилет мак 3 кассеты, станки для бритья джиллет фьюжен повер, а также любой другой продукт линейки gillette mach 3 по специальной цене!. Хит продаж одноразовые станки gillette blue 2.

    ReplyDelete

Post a Comment

Popular posts from this blog

Biotech Leaders Call for a Free Press

BIO and Topless Dancers: Where to Cast Our Ayes